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231224s2017 xx |||||o 00| ||eng c |
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|a 10.5713/ajas.16.0077
|2 doi
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|a pubmed24n0873.xml
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|a (DE-627)NLM26211464X
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|a (NLM)27383799
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xing, Shen
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets
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| 264 |
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1 |
|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Revised 01.10.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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| 520 |
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|a OBJECTIVE: The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets
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| 520 |
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|a METHODS: A total of 180 barrows with initial weight 10.01±0.03 kg were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), respectively
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| 520 |
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|a RESULTS: The results showed that in comparison with control diet, dietary Ala-Gln supplementation increased the height of villi in duodenum and jejunum (p<0.05), Gln supplementation increased the villi height of jejunum (p<0.05), Ala-Gln supplementation up-regulated the mRNA expressions of epidermal growth factor receptor and insulin-like growth factor 1 receptor in jejunal mucosa (p<0.05), raised the mRNA expressions of Claudin-1, Occludin, zonula occludens protein-1 (ZO-1) and the protein levels of Occludin, ZO-1 in jejunal mucosa (p<0.05), Ala-Gln supplementation enlarged the number of goblet cells in duodenal and ileal epithelium (p<0.05), Gln increased the number of goblet cells in duodenal epithelium (p<0.05) and Ala-Gln supplementation improved the concentrations of secretory immunoglobulin A and immunoglobulin G in the jejunal mucosa (p<0.05)
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| 520 |
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|a CONCLUSION: These results demonstrated that dietary Ala-Gln supplementation could maintain the integrity of small intestine and promote the functions of intestinal mucosa barriers in piglets
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4 |
|a Journal Article
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4 |
|a Alanyl-glutamine
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| 650 |
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4 |
|a Glutamine
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| 650 |
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4 |
|a Mucosa Barrier
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| 650 |
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4 |
|a Piglet
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| 650 |
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4 |
|a Small Intestine
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| 700 |
1 |
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|a Zhang, Bolin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Meng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jiaolong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Guanghong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Asian-Australasian journal of animal sciences
|d 1998
|g 30(2017), 2 vom: 14. Feb., Seite 236-245
|w (DE-627)NLM098195883
|x 1011-2367
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2017
|g number:2
|g day:14
|g month:02
|g pages:236-245
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| 856 |
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|u http://dx.doi.org/10.5713/ajas.16.0077
|3 Volltext
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