Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies

Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies

Copyright © 2016 John Wiley & Sons, Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Magnetic resonance in chemistry : MRC. - 1985. - 54(2016), 12 vom: 12. Dez., Seite 953-961
1. Verfasser: Szwarc, Katarzyna (VerfasserIn)
Weitere Verfasser: Płosiński, Marcin, Czerniejewska, Karolina, Laskowski, Tomasz, Leniak, Arkadiusz, Czub, Jacek, Kubica, Paweł, Sowiński, Paweł, Pawlak, Jan, Borowski, Edward
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Magnetic resonance in chemistry : MRC
Schlagworte:Journal Article 13C 1H NMR iso-nystatin A1 isomeric form molecular modeling nystatin A1 translactonization Antifungal Agents mehr... Lactones Nystatin 1400-61-9
Beschreibung
Zusammenfassung:Copyright © 2016 John Wiley & Sons, Ltd.
Nystatin A1 , a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A1 with lactone ring diminished by two carbon atoms. Structural evidence is provided by advanced NMR and Mass Spectrometry (MS) studies. Molecular dynamics simulations and quantum mechanics calculations gave the insight into the course and mechanism of the transformation and its effect on the conformation of the subject molecule. Copyright © 2016 John Wiley & Sons, Ltd
Beschreibung:Date Completed 05.02.2018
Date Revised 05.02.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1097-458X
DOI:10.1002/mrc.4478