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231224s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.06.017
|2 doi
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|a eng
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| 100 |
1 |
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|a Pierson, Emily R
|e verfasserin
|4 aut
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| 245 |
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4 |
|a The contribution of neutrophils to CNS autoimmunity
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 01.07.2019
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|a Date Revised 14.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Multiple sclerosis (MS) is believed to be initiated when myelin-specific T cells infiltrate the central nervous system (CNS), triggering subsequent recruitment of inflammatory leukocytes to the CNS. The contribution of neutrophils to CNS autoimmune disease has been underappreciated, but several studies in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, indicate that neutrophils have an important role in inflammation. Neutrophils are hypothesized to contribute to the pathogenesis of EAE by producing cytokines and promoting breakdown of the blood brain barrier. Neutrophils may also influence the manifestation of EAE by facilitating parenchymal brain inflammation. This review summarizes evidence supporting a functional role for neutrophils in EAE and MS, highlighting the differential regulation of neutrophil recruitment in the brain and spinal cord
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a CXCR2
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|a EAE
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|a IL-17
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| 650 |
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|a MS
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| 650 |
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|a Neutrophils
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| 650 |
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|a Cytokines
|2 NLM
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| 700 |
1 |
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|a Wagner, Catriona A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Goverman, Joan M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 189(2018) vom: 05. Apr., Seite 23-28
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|x 1521-7035
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|g volume:189
|g year:2018
|g day:05
|g month:04
|g pages:23-28
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|u http://dx.doi.org/10.1016/j.clim.2016.06.017
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