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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.06.009
|2 doi
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|a pubmed24n0873.xml
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|a (DE-627)NLM261968238
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|a (NLM)27368806
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|a (PII)S1521-6616(16)30117-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wang, Ninghai
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Slamf6 negatively regulates autoimmunity
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| 264 |
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 31.05.2017
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|a Date Revised 23.10.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6-/- B6 CD4+ T cells into co-isogenic bm12 mice causes SLE-like autoimmunity with elevated levels of autoantibodies. In addition, significantly higher percentages of Tfh cells and IFN-γ-producing CD4+ cells, as well as GC B cells were observed. Interestingly, the expression of the Slamf6-H1 isoform in Slamf6-/- CD4+ T cells did not induce this lupus-like phenotype. By contrast, Slamf1-/- or Slamf5-/- CD4+ T cells caused the same pathology as WT CD4+ T cells. As the transfer of Slamf [1+6]-/- or Slamf [1+5+6]-/- CD4+ T cells induced WT levels of autoantibodies, the presence of Slamf1 was requisite for the induction of increased levels of autoantibodies by Slamf6-/- CD4+ T cells. We conclude that Slamf6 functions as an inhibitory receptor that controls autoimmune responses
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Autoantibody
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| 650 |
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4 |
|a GVH
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| 650 |
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4 |
|a Slamf6
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| 650 |
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4 |
|a Tfh cells
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| 650 |
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|a Autoantibodies
|2 NLM
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| 650 |
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|a Cd84 protein, mouse
|2 NLM
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| 650 |
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|a Signaling Lymphocytic Activation Molecule Family
|2 NLM
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| 650 |
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7 |
|a Slamf1 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Slamf6 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Signaling Lymphocytic Activation Molecule Family Member 1
|2 NLM
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| 650 |
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7 |
|a 169535-43-7
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Keszei, Marton
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Halibozek, Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yigit, Burcu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Engel, Pablo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Terhorst, Cox
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 173(2016) vom: 01. Dez., Seite 19-26
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:173
|g year:2016
|g day:01
|g month:12
|g pages:19-26
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2016.06.009
|3 Volltext
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