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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.06.006
|2 doi
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|a pubmed24n0872.xml
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Öckinger, Johan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis
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| 264 |
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 31.03.2017
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|a Date Revised 13.08.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Cigarette smoking is a risk factor for multiple sclerosis (MS), and the risk is further multiplied for HLA-DRB1*15(+) smokers. To define the smoke-induced immune responses in the lung we performed bronchoscopy with bronchoalveolar lavage (BAL) on smokers and non-smokers, both MS-patients and healthy volunteers. In the BAL, non-smokers with MS showed an increased preformed CD40L expression in CD4(+) T-cells while smokers displayed an increase in proliferating (Ki-67(+)) T-cells. In addition, our results confirm that smoking induces an increase of alveolar macrophages in BAL, and further defined a significant attenuation of this response in carriers of the HLA-DRB1*15 allele, in both MS patients and healthy controls. This first systematic investigation of the immune response in the lungs of smokers and non-smokers diagnosed with MS, thus suggests an MS-associated lung T-cell phenotype, involvement of a specific T-cell response to smoke, and a genetic regulation of the macrophage response
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a HLA-DRB1 Chains
|2 NLM
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| 650 |
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|a Ki-67 Antigen
|2 NLM
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| 650 |
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|a CD40 Ligand
|2 NLM
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|a 147205-72-9
|2 NLM
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| 700 |
1 |
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|a Hagemann-Jensen, Michael
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kullberg, Susanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Engvall, Benita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eklund, Anders
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Grunewald, Johan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Piehl, Fredrik
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Olsson, Tomas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wahlström, Jan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 169(2016) vom: 28. Aug., Seite 114-120
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:169
|g year:2016
|g day:28
|g month:08
|g pages:114-120
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|u http://dx.doi.org/10.1016/j.clim.2016.06.006
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