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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201601778
|2 doi
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|a eng
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|a Sun, Tiedong
|e verfasserin
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|a Target Delivery of a Novel Antitumor Organoplatinum(IV)-Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo
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|c 2016
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|a Text
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|a ƒaComputermedien
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|a Date Completed 18.10.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a An inactive organoplatinum(IV)-substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of Pt(IV) -PW11 with DSPE-PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such Pt(IV) -PW11 -DSPE-PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin
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|a antitumor activity
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|a micelles
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|a polyoxometalates
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|a target delivery
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|a Antineoplastic Agents
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|a Prodrugs
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|a Tungsten Compounds
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|a polyoxometalate I
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|a Cisplatin
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|a Cui, Wei
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|a Yan, Mei
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|a Gu, Hongxi
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|a Liu, Shaoqin
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|a Wu, Qiong
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 28(2016), 34 vom: 01. Sept., Seite 7397-404
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