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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erw210
|2 doi
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|a pubmed25n0869.xml
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|a DE-627
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|e rakwb
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|a eng
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|a Weidmann, Joachim
|e verfasserin
|4 aut
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|a Discovery, structure, function, and applications of cyclotides
|b circular proteins from plants
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 21.11.2017
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|a Date Revised 13.01.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants from the Violaceae, Rubiaceae, Cucurbitaceae, Fabaceae, and Solanaceae families, typically with 10-100 cyclotides in a given plant species, in a wide range of tissues, including flowers, leaves, stems, and roots. Some cyclotides are expressed in large amounts (up to 1g kg(-1) wet plant weight) and their natural function appears to be to protect plants from pests or pathogens. This article provides a brief overview of their discovery, distribution in plants, and applications. In particular, their exceptional stability has led to their use as peptide-based scaffolds in drug design applications. They also have potential as natural 'ecofriendly' insecticides, and as protein engineering frameworks
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|a Journal Article
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|a Review
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|a Research Support, Non-U.S. Gov't
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|a Cyclic peptides
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|a cyclotides
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|a drug design
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|a insecticide
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|a kalata B1
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|a plant defence.
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|a Cyclotides
|2 NLM
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| 650 |
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|a Plant Proteins
|2 NLM
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| 700 |
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|a Craik, David J
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 67(2016), 16 vom: 24. Aug., Seite 4801-12
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:67
|g year:2016
|g number:16
|g day:24
|g month:08
|g pages:4801-12
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|u http://dx.doi.org/10.1093/jxb/erw210
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