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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b04653
|2 doi
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|a pubmed25n0868.xml
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|a eng
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| 100 |
1 |
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|a Kang, Eunae
|e verfasserin
|4 aut
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| 245 |
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|a Shape-Encoded Chitosan-Polyacrylamide Hybrid Hydrogel Microparticles with Controlled Macroporous Structures via Replica Molding for Programmable Biomacromolecular Conjugation
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|c 2016
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|a Text
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 21.05.2018
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|a Date Revised 21.05.2018
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Polymeric hydrogel microparticle-based suspension arrays with shape-based encoding offer powerful alternatives to planar and bead-based arrays toward high throughput biosensing and medical diagnostics. We report a simple and robust micromolding technique for polyacrylamide- (PAAm-) based biopolymeric-synthetic hybrid microparticles with controlled 2D shapes containing a potent aminopolysaccharide chitosan as an efficient conjugation handle uniformly incorporated in PAAm matrix. A postfabrication conjugation approach utilizing amine-reactive chemistries on the chitosan shows stable incorporation and retained chemical reactivity of chitosan, readily tunable macroporous structures via simple addition of low content long-chain PEG porogens for improved conjugation capacity and kinetics, and one-pot biomacromolecular assembly via bioorthogonal click reactions with minimal nonspecific binding. We believe that the integrated fabrication-conjugation approach reported here could offer promising routes to programmable manufacture of hydrogel microparticle-based biomacromolecular conjugation and biofunctionalization platforms for a large range of applications
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|a Journal Article
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|a Jung, Sukwon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abel, John H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pine, Allison
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yi, Hyunmin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 32(2016), 21 vom: 31. Mai, Seite 5394-402
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:32
|g year:2016
|g number:21
|g day:31
|g month:05
|g pages:5394-402
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|u http://dx.doi.org/10.1021/acs.langmuir.5b04653
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