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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.6b00284
|2 doi
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|a pubmed24n0867.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Filippov, Sergey K
|e verfasserin
|4 aut
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| 245 |
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|a Internal Nanoparticle Structure of Temperature-Responsive Self-Assembled PNIPAM-b-PEG-b-PNIPAM Triblock Copolymers in Aqueous Solutions
|b NMR, SANS, and Light Scattering Studies
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 21.05.2018
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|a Date Revised 21.05.2018
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a In this study, we report detailed information on the internal structure of PNIPAM-b-PEG-b-PNIPAM nanoparticles formed from self-assembly in aqueous solutions upon increase in temperature. NMR spectroscopy, light scattering, and small-angle neutron scattering (SANS) were used to monitor different stages of nanoparticle formation as a function of temperature, providing insight into the fundamental processes involved. The presence of PEG in a copolymer structure significantly affects the formation of nanoparticles, making their transition to occur over a broader temperature range. The crucial parameter that controls the transition is the ratio of PEG/PNIPAM. For pure PNIPAM, the transition is sharp; the higher the PEG/PNIPAM ratio results in a broader transition. This behavior is explained by different mechanisms of PNIPAM block incorporation during nanoparticle formation at different PEG/PNIPAM ratios. Contrast variation experiments using SANS show that the structure of nanoparticles above cloud point temperatures for PNIPAM-b-PEG-b-PNIPAM copolymers is drastically different from the structure of PNIPAM mesoglobules. In contrast with pure PNIPAM mesoglobules, where solidlike particles and chain network with a mesh size of 1-3 nm are present, nanoparticles formed from PNIPAM-b-PEG-b-PNIPAM copolymers have nonuniform structure with "frozen" areas interconnected by single chains in Gaussian conformation. SANS data with deuterated "invisible" PEG blocks imply that PEG is uniformly distributed inside of a nanoparticle. It is kinetically flexible PEG blocks which affect the nanoparticle formation by prevention of PNIPAM microphase separation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Bogomolova, Anna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kaberov, Leonid
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Velychkivska, Nadiia
|e verfasserin
|4 aut
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| 700 |
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|a Starovoytova, Larisa
|e verfasserin
|4 aut
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|a Cernochova, Zulfiya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rogers, Sarah E
|e verfasserin
|4 aut
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| 700 |
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|a Lau, Wing Man
|e verfasserin
|4 aut
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| 700 |
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|a Khutoryanskiy, Vitaliy V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cook, Michael T
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 32(2016), 21 vom: 31. Mai, Seite 5314-23
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:32
|g year:2016
|g number:21
|g day:31
|g month:05
|g pages:5314-23
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|u http://dx.doi.org/10.1021/acs.langmuir.6b00284
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