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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-016-1662-6
|2 doi
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|a pubmed24n0866.xml
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|a (DE-627)NLM260084794
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|a (NLM)27151403
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Huang, Andrew C
|e verfasserin
|4 aut
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| 245 |
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|a Increased rodenticide exposure rate and risk of toxicosis in barn owls (Tyto alba) from southwestern Canada and linkage with demographic but not genetic factors
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.01.2017
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|a Date Revised 21.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Among many anthropogenic drivers of population decline, continual rapid urbanization and industrialization pose major challenges for the survival of wildlife species. Barn owls (Tyto alba) in southwestern British Columbia (BC) face a multitude of threats ranging from habitat fragmentation to vehicle strikes. They are also at risk from secondary poisoning of second-generation anticoagulant rodenticides (SGARs), a suite of toxic compounds which at high doses results in a depletion of blood clotting factors leading to internal bleeding and death. Here, using long-term data (N = 119) for the hepatic residue levels of SGAR, we assessed the risk of toxicosis from SGAR for the BC barn owl population over the past two decades. We also investigated whether sensitivity to SGAR is associated with genetic factors, namely Single Nucleotide Polymorphisms (SNPs) found in the CYP2C45 gene of barn owls. We found that residue concentration for total SGAR was significantly higher in 2006-2013 (141 ng/g) relative to 1992-2003 (57 ng/g). The proportion of owls exposed to multiple SGAR types was also significantly higher in 2006-2013. Those measures accordingly translate directly into an increase in toxicosis risk level. We also detected demographic differences, where adult females showed on average lower concentration of total SGAR (64 ng/g) when compared to adult males (106 ng/g). Juveniles were overall more likely to show signs of toxicosis than adults (33.3 and 6.9 %, respectively), and those symptoms were positively predicted by SGAR concentrations. We found no evidence that SNPs in the CYP2C45 gene of barn owls were associated with intraspecific variation in SGAR sensitivity. We recommend several preventative measures be taken to minimize wildlife exposure to SGAR
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4 |
|a Journal Article
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4 |
|a Barn owl
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| 650 |
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4 |
|a British Columbia
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4 |
|a Cytochrome P450 gene
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| 650 |
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4 |
|a Demographic differences
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| 650 |
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4 |
|a Second-generation anticoagulant rodenticide (SGAR)
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4 |
|a Temporal differences
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| 650 |
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7 |
|a Anticoagulants
|2 NLM
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| 650 |
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7 |
|a Environmental Pollutants
|2 NLM
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| 650 |
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7 |
|a Rodenticides
|2 NLM
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| 700 |
1 |
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|a Elliott, John E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hindmarch, Sofi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Sandi L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maisonneuve, France
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bowes, Victoria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Kimberly M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martin, Kathy
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 25(2016), 6 vom: 24. Aug., Seite 1061-71
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
8 |
|g volume:25
|g year:2016
|g number:6
|g day:24
|g month:08
|g pages:1061-71
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| 856 |
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|u http://dx.doi.org/10.1007/s10646-016-1662-6
|3 Volltext
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|a GBV_ILN_350
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|a AR
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|d 25
|j 2016
|e 6
|b 24
|c 08
|h 1061-71
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