Pharmacogenomics study of 620 whole-exome sequencing focusing on aspirin application

Pharmacogenomics study of 620 whole-exome sequencing : focusing on aspirin application

OBJECTIVE: To investigate the allele frequencies of aspirin-response-related variants in different population

Détails bibliographiques
Publié dans:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 54(2016), 5 vom: 03. Mai, Seite 332-6
Auteur principal: Yang, L (Auteur)
Autres auteurs: Lu, Y L, Wang, H J, Zhou, W H
Format: Article en ligne
Langue:Chinese
Publié: 2016
Accès à la collection:Zhonghua er ke za zhi = Chinese journal of pediatrics
Sujets:Journal Article Aspirin R16CO5Y76E
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520 |a OBJECTIVE: To investigate the allele frequencies of aspirin-response-related variants in different population 
520 |a METHOD: The allele frequencies of reported clinically significant aspirin-response-related variants were evaluated based on 620 whole exome sequencing (WES) data collected from 2013 to 2016 in Children's Hospital of Fudan University.Then the local allele frequencies were compared with 1 000 Genomes project database, and χ(2) test was used 
520 |a RESULT: Thirty-eight aspirin-response-related variants that had clinical significance had been detected in the 620 WES data.Ten (26%) of them were related with drug efficacy while 28 (74%) were related with toxicity or adverse drug reaction (ADR). These variants were distributed in 33 genes.There were 23 aspirin-related variants further analysised, and the frequency of 7 (rs1050891, rs6065, rs7862221, rs1065776, rs3818822, rs3775291 and rs1126643) had no significant difference compared with frequency of European and East Asian population of 1 000 Genome project (P>0.01 for both), 10 (rs2228079, rs1613662, rs4523, rs28360521, rs1131882, rs1047626, rs3856806, rs2768759, rs7572857 and rs1126510) of them had no significant difference compared with East Asian but were significantly different from European population, 1 (rs2075797) had no significant difference compared with frequency of European and different with frequency of East Asian, and 5 variants(rs10279545, rs730012, rs16851030, rs1353411, rs1800469)were different from frequency of both East Asian(0.019, 0.058, 0.167, 0.452, 0.340 vs. 0.100, 0.151, 0.396, 0.568, 0.453, χ(2)=21.798, 20.400, 67.543, 16.531, 15.807, P all<0.01) and European population(0.531, 0.312, 0.037, 0.179, 0.688, χ(2)=325.799, 92.877, 144.811, 156.471, 174.533, P all<0.01) 
520 |a CONCLUSION: Most variants that have clinical significance in aspirin response are related with drug efficacy or drug toxicity or ADR, indicating the urgency of variants screen in clinical practice.Significant population-specificity is detected in local 620 WES data in aspirin-response-related variants 
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700 1 |a Lu, Y L  |e verfasserin  |4 aut 
700 1 |a Wang, H J  |e verfasserin  |4 aut 
700 1 |a Zhou, W H  |e verfasserin  |4 aut 
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