Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells

Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells

Copyright © 2016 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 168(2016) vom: 15. Juli, Seite 6-15
1. Verfasser: Coelho-Dos-Reis, Jordana G (VerfasserIn)
Weitere Verfasser: Huang, Jing, Tsao, Tiffany, Pereira, Felipe V, Funakoshi, Ryota, Nakajima, Hiroko, Sugiyama, Haruo, Tsuji, Moriya
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Adjuvant CD1d Cancer vaccine Circumsporozoite protein Glycolipid Malaria vaccine Memory-like effector NKT cells NKT cells mehr... TLR4 WT-1 7DW8-5 glycolipid Epitopes, T-Lymphocyte Galactosylceramides HLA-A2 Antigen Lipid A Peptides Protective Agents Protozoan Proteins Toll-Like Receptor 4 WT1 Proteins circumsporozoite protein, Protozoan Interferon-gamma 82115-62-6 monophosphoryl lipid A MWC0ET1L2P
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100 1 |a Coelho-Dos-Reis, Jordana G  |e verfasserin  |4 aut 
245 1 0 |a Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells 
264 1 |c 2016 
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500 |a Date Completed 30.03.2017 
500 |a Date Revised 02.01.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2016 Elsevier Inc. All rights reserved. 
520 |a In the present study, the combined adjuvant effect of 7DW8-5, a potent α-GalCer-analog, and monophosphoryl lipid A (MPLA), a TLR4 agonist, on the induction of vaccine-induced CD8(+) T-cell responses and protective immunity was evaluated. Mice were immunized with peptides corresponding to the CD8(+) T-cell epitopes of a malaria antigen, a circumsporozoite protein of Plasmodium yoelii, and a tumor antigen, a Wilms Tumor antigen-1 (WT-1), together with 7DW8-5 and MPLA, as an adjuvant. These immunization regimens were able to induce higher levels of CD8(+) T-cell responses and, ultimately, enhanced levels of protection against malaria and tumor challenges compared to the levels induced by immunization with peptides mixed with 7DW8-5 or MPLA alone. Co-administration of 7DW8-5 and MPLA induces activation of memory-like effector natural killer T (NKT) cells, i.e. CD44(+)CD62L(-)NKT cells. Our study indicates that 7DW8-5 greatly enhances important synergistic pathways associated to memory immune responses when co-administered with MPLA, thus rendering this combination of adjuvants a novel vaccine adjuvant formulation 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Adjuvant 
650 4 |a CD1d 
650 4 |a Cancer vaccine 
650 4 |a Circumsporozoite protein 
650 4 |a Glycolipid 
650 4 |a Malaria vaccine 
650 4 |a Memory-like effector NKT cells 
650 4 |a NKT cells 
650 4 |a TLR4 
650 4 |a WT-1 
650 7 |a 7DW8-5 glycolipid  |2 NLM 
650 7 |a Epitopes, T-Lymphocyte  |2 NLM 
650 7 |a Galactosylceramides  |2 NLM 
650 7 |a HLA-A2 Antigen  |2 NLM 
650 7 |a Lipid A  |2 NLM 
650 7 |a Peptides  |2 NLM 
650 7 |a Protective Agents  |2 NLM 
650 7 |a Protozoan Proteins  |2 NLM 
650 7 |a Toll-Like Receptor 4  |2 NLM 
650 7 |a WT1 Proteins  |2 NLM 
650 7 |a circumsporozoite protein, Protozoan  |2 NLM 
650 7 |a Interferon-gamma  |2 NLM 
650 7 |a 82115-62-6  |2 NLM 
650 7 |a monophosphoryl lipid A  |2 NLM 
650 7 |a MWC0ET1L2P  |2 NLM 
700 1 |a Huang, Jing  |e verfasserin  |4 aut 
700 1 |a Tsao, Tiffany  |e verfasserin  |4 aut 
700 1 |a Pereira, Felipe V  |e verfasserin  |4 aut 
700 1 |a Funakoshi, Ryota  |e verfasserin  |4 aut 
700 1 |a Nakajima, Hiroko  |e verfasserin  |4 aut 
700 1 |a Sugiyama, Haruo  |e verfasserin  |4 aut 
700 1 |a Tsuji, Moriya  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 168(2016) vom: 15. Juli, Seite 6-15  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:168  |g year:2016  |g day:15  |g month:07  |g pages:6-15 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2016.04.014  |3 Volltext 
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