Aggregation of Antibody Drug Conjugates at Room Temperature : SAXS and Light Scattering Evidence for Colloidal Instability of a Specific Subpopulation
Coupling a hydrophobic drug onto monoclonal antibodies via lysine residues is a common route to prepare antibody-drug conjugates (ADC), a promising class of biotherapeutics. But a few chemical modifications on protein surface often increase aggregation propensity, without a clear understanding of th...
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Bibliographische Detailangaben
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 32(2016), 19 vom: 17. Mai, Seite 4848-61
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| 1. Verfasser: |
Frka-Petesic, B
(VerfasserIn) |
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| Weitere Verfasser: |
Zanchi, D,
Martin, N,
Carayon, S,
Huille, S,
Tribet, C |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2016
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Buffers
Colloids
Immunoconjugates |
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