Disruption of OsSULTR3;3 reduces phytate and phosphorus concentrations and alters the metabolite profile in rice grains

Disruption of OsSULTR3;3 reduces phytate and phosphorus concentrations and alters the metabolite profile in rice grains

© 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1990. - 211(2016), 3 vom: 01. Aug., Seite 926-39
1. Verfasser: Zhao, Haijun (VerfasserIn)
Weitere Verfasser: Frank, Thomas, Tan, Yuanyuan, Zhou, Chenguang, Jabnoune, Mehdi, Arpat, A Bulak, Cui, Hairui, Huang, Jianzhong, He, Zuhua, Poirier, Yves, Engel, Karl-Heinz, Shu, Qingyao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't anti-nutrient metabolite profiling phosphate transporter phosphorus phytic acid rice (Oryza sativa) sulfate transporter γ-aminobutyric acid mehr... Anion Transport Proteins Plant Proteins Sulfates Phosphorus 27YLU75U4W Sulfur 70FD1KFU70 Phytic Acid 7IGF0S7R8I Glucuronidase EC 3.2.1.31
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520 |a Two low phytic acid (lpa) mutants have been developed previously with the aim to improve the nutritional value of rice (Oryza sativa) grains. In the present study, the impacts of lpa mutations on grain composition and underlying molecular mechanisms were investigated. Comparative compositional analyses and metabolite profiling demonstrated that concentrations of both phytic acid (PA) and total phosphorus (P) were significantly reduced in lpa brown rice, accompanied by changes in other metabolites and increased concentrations of nutritionally relevant compounds. The lpa mutations modified the expression of a number of genes involved in PA metabolism, as well as in sulfate and phosphate homeostasis and metabolism. Map-based cloning and complementation identified the underlying lpa gene to be OsSULTR3;3. The promoter of OsSULTR3;3 is highly active in the vascular bundles of leaves, stems and seeds, and its protein is localized in the endoplasmic reticulum. No activity of OsSULTR3;3 was revealed for the transport of phosphate, sulfate, inositol or inositol 1,4,5 triphosphate by heterologous expression in either yeast or Xenopus oocytes. The findings reveal that OsSULTR3;3 plays an important role in grain metabolism, pointing to a new route to generate value-added grains in rice and other cereal crops 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a anti-nutrient 
650 4 |a metabolite profiling 
650 4 |a phosphate transporter 
650 4 |a phosphorus 
650 4 |a phytic acid 
650 4 |a rice (Oryza sativa) 
650 4 |a sulfate transporter 
650 4 |a γ-aminobutyric acid 
650 7 |a Anion Transport Proteins  |2 NLM 
650 7 |a Plant Proteins  |2 NLM 
650 7 |a Sulfates  |2 NLM 
650 7 |a Phosphorus  |2 NLM 
650 7 |a 27YLU75U4W  |2 NLM 
650 7 |a Sulfur  |2 NLM 
650 7 |a 70FD1KFU70  |2 NLM 
650 7 |a Phytic Acid  |2 NLM 
650 7 |a 7IGF0S7R8I  |2 NLM 
650 7 |a Glucuronidase  |2 NLM 
650 7 |a EC 3.2.1.31  |2 NLM 
700 1 |a Frank, Thomas  |e verfasserin  |4 aut 
700 1 |a Tan, Yuanyuan  |e verfasserin  |4 aut 
700 1 |a Zhou, Chenguang  |e verfasserin  |4 aut 
700 1 |a Jabnoune, Mehdi  |e verfasserin  |4 aut 
700 1 |a Arpat, A Bulak  |e verfasserin  |4 aut 
700 1 |a Cui, Hairui  |e verfasserin  |4 aut 
700 1 |a Huang, Jianzhong  |e verfasserin  |4 aut 
700 1 |a He, Zuhua  |e verfasserin  |4 aut 
700 1 |a Poirier, Yves  |e verfasserin  |4 aut 
700 1 |a Engel, Karl-Heinz  |e verfasserin  |4 aut 
700 1 |a Shu, Qingyao  |e verfasserin  |4 aut 
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