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231224s2016 xx ||||| 00| ||eng c |
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|a pubmed25n0864.xml
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|a (DE-627)NLM259491055
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|a (NLM)27087736
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Hoover, Andrew J
|e verfasserin
|4 aut
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|a A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Revised 01.10.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Translation of new 18F-fluorination reactions to produce radiotracers for human positron emission tomography (PET) imaging is rare because the chemistry must have useful scope and the process for 18F-labeled tracer production must be robust and simple to execute. The application of transition metal mediators has enabled impactful 18F-fluorination methods, but to date none of these reactions have been applied to produce a human-injectable PET tracer. In this article we present chemistry and process innovations that culminate in the first production from [18F]fluoride of human doses of [18F]5-fluorouracil, a PET tracer for cancer imaging in humans. The first preparation of nickel σ-aryl complexes by transmetalation from arylboronic acids or esters was developed and enabled the synthesis of the [18F]5-fluorouracil precursor. Routine production of >10 mCi doses of [18F]5-fluorouracil was accomplished with a new instrument for azeotrope-free [18F]fluoride concentration in a process that leverages the tolerance of water in nickel-mediated 18F-fluorination
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|a Journal Article
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|a Lazari, Mark
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ren, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Narayanam, Maruthi Kumar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Murphy, Jennifer M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van Dam, R Michael
|e verfasserin
|4 aut
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1 |
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|a Hooker, Jacob M
|e verfasserin
|4 aut
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| 700 |
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|a Ritter, Tobias
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Organometallics
|d 1998
|g 35(2016), 7 vom: 11. Apr., Seite 1008-1014
|w (DE-627)NLM098167103
|x 0276-7333
|7 nnas
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| 773 |
1 |
8 |
|g volume:35
|g year:2016
|g number:7
|g day:11
|g month:04
|g pages:1008-1014
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|a GBV_USEFLAG_A
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|a GBV_ILN_350
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|a AR
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|d 35
|j 2016
|e 7
|b 11
|c 04
|h 1008-1014
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