Impaired selective cytokine production by CD4(+) T cells in Common Variable Immunodeficiency associated with the absence of memory B cells

Impaired selective cytokine production by CD4(+) T cells in Common Variable Immunodeficiency associated with the absence of memory B cells

Copyright © 2016 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 166-167(2016) vom: 01. Mai, Seite 19-26
1. Verfasser: Berrón-Ruiz, Laura (VerfasserIn)
Weitere Verfasser: López-Herrera, Gabriela, Vargas-Hernández, Alexander, Santos-Argumedo, Leopoldo, López-Macías, Constantino, Isibasi, Armando, Segura-Méndez, Nora Hilda, Bonifaz, Laura
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Activation Co-stimulation Common variable immunodeficiency Cytokine Memory B cells T helper cells B-Cell Activation Factor Receptor B7-H1 Antigen mehr... CD274 protein, human CTLA-4 Antigen ICOS protein, human IL10 protein, human IL13 protein, human IL17A protein, human IL9 protein, human Inducible T-Cell Co-Stimulator Protein Interleukin-13 Interleukin-17 Interleukin-9 PDCD1 protein, human Programmed Cell Death 1 Receptor TNFRSF13C protein, human Interleukin-10 130068-27-8
Beschreibung
Zusammenfassung:Copyright © 2016 Elsevier Inc. All rights reserved.
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency characterized by B cell dysfunction and decreased serum immunoglobulin. CVID patients are classified by the absence or presence of memory B cells. In addition, T cell defects have been demonstrated in only a proportion of CVID patients. The aim of this study was to evaluate the function of CD4(+) T cells from CVID patients and its association with memory B cells. Patients were classified according to their Freiburg groups: group Ia and Ib, with decreased switched memory B cells (<0.4 of PBL), and group II, with normal B cell subsets. Their T cell function was evaluated after stimulation. We observed normal and even increased CD4(+) T cell proliferation in group Ia (p=0.0277). The proliferation positively correlated with the clinical severity score (r=0.4796). We observed lower levels of IL-17A and IL-10 in group Ia (p=0.0177, 0.0109) and Ib (p=0.0009, 0.0084) patients. Group Ib patients also had low levels of IL-13 and IL-9 (p=0.0169, 0.010). Group II patients had similar cytokine production to that of the controls. BAFFR expression was reduced in groups Ia (p=0.0001) and Ib (p=0.0002) and showed an inverse correlation with the severity score (p=0.0262; r=0.5371). ICOS expression was reduced in group Ia (p=0.0364), and PD-1 was increased in group Ib (p=0.0432) patients. This study shows a selective impairment in cytokine production in group Ia patients, which was more extensive than in group Ib patients. The impairment was associated with BAFFR expression in B cells, with ICOS and PD-1 in T cells and, remarkably, with the absence of memory B cells and with the disease severity. Our results suggest that the evaluation of cytokine expression by T cells in combination with the study of B cell memory could be important for understand the pathogenesis of CVID patients
Beschreibung:Date Completed 21.03.2017
Date Revised 19.11.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2016.03.013