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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.jsha.2015.07.002
|2 doi
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|a pubmed24n0863.xml
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|a (DE-627)NLM259166162
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|a (NLM)27053897
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ranganayakulu, K P
|e verfasserin
|4 aut
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| 245 |
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|a N-terminal-pro-brain natriuretic peptide, a surrogate biomarker of combined clinical and hemodynamic outcomes following percutaneous transvenous mitral commissurotomy
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.04.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a AIM: To examine the relationship between plasma levels of N-terminal-proB type natriuretic peptide (NT-proBNP) and various echocardiographic and hemodynamic parameters in patients with mitral stenosis undergoing percutaneous transvenous mitral commissurotomy (PTMC)
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|a MATERIALS AND METHODS: The study population consisted of 100 patients with rheumatic mitral stenosis who underwent PTMC. NT-proBNP levels in these patients were measured before PTMC and 48 hours after PTMC. These levels were then correlated with various echocardiographic and hemodynamic parameters measured before and after PTMC
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|a RESULTS: Eighty-one percent of the study population were women, and the most common presenting symptom was dyspnea which was present in 94% of the patients. Dyspnea New York Heart Association class correlated significantly with baseline NT-proBNP levels (r = 0.63; p < 0.01). The plasma NT-proBNP levels in these patients increased as echocardiogram signs of left atrial enlargement and right ventricular hypertrophy developed (r = 0.59, p < 0.01). Patients in atrial fibrillation had significantly higher NT-proBNP levels than patients in sinus rhythm. Baseline NT-proBNP levels correlated significantly with left atrial volume (r = 0.38; p < 0.01), left atrial volume index (r = 0.45; p < 0.01), systolic pulmonary artery pressures (r = 0.42; p < 0.01), and mean pulmonary artery pressures (r = 0.41; p < 0.01). All patients who underwent successful PTMC showed a significant decrease in NT-proBNP (decreased from a mean 763.8 pg/mL to 348.6 pg/mL) along with a significant improvement in all echocardiographic and hemodynamic parameters (p < 0.01). The percent change in NT-proBNP correlated significantly with the percent improvement noted with left atrial volume (r = 0.39; p < 0.01), left atrial volume index (r = 0.41; p < 0.01), systolic (r = 0.32, p < 0.01), and mean pulmonary artery pressures (r = 0.31, p < 0.01)
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|a CONCLUSIONS: The decrease in NT-proBNP levels following PTMC reflects an improvement in clinical and hemodynamic status; hence, it is reasonable to suggest that NT-proBNP is helpful in evaluating the response to PTMC
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|a Journal Article
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|a Balloon mitral valvotomy
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| 650 |
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|a Left atrial volume
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|a Mitral stenosis
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| 650 |
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|a N-terminal-proB type natriuretic peptide
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| 650 |
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|a Percutaneous transvenous mitral commissurotomy
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| 650 |
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|a Pulmonary artery pressures
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| 700 |
1 |
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|a Rajasekhar, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vanajakshamma, V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Santosh Kumar, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vasudeva Chetty, P
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of the Saudi Heart Association
|d 1999
|g 28(2016), 2 vom: 15. Apr., Seite 81-8
|w (DE-627)NLM098225227
|x 1016-7315
|7 nnns
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| 773 |
1 |
8 |
|g volume:28
|g year:2016
|g number:2
|g day:15
|g month:04
|g pages:81-8
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.jsha.2015.07.002
|3 Volltext
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