Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease : Consequences for Epigenetic Regulation of rDNA and Cognition

Synaptic dysfunction is thought to play a major role in memory impairment in Alzheimer's disease (AD). PARP-1 has been identified as an epigenetic regulator of plasticity and memory. Thus, we hypothesize that PARP-1 may be altered in postmortem hippocampus of individuals with AD compared to age...

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Publié dans:	Neural plasticity. - 1998. - 2016(2016) vom: 05., Seite 8987928
Auteur principal:	Zeng, Jianying (Auteur)
Autres auteurs:	Libien, Jenny, Shaik, Fatima, Wolk, Jason, Hernández, A Iván
Format:	Article en ligne
Langue:	English
Publié:	2016
Accès à la collection:	Neural plasticity
Sujets:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Chromosomal Proteins, Non-Histone DNA, Ribosomal fibrillarin PARP1 protein, human EC 2.4.2.30 Poly (ADP-Ribose) Polymerase-1