Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease : Consequences for Epigenetic Regulation of rDNA and Cognition
Synaptic dysfunction is thought to play a major role in memory impairment in Alzheimer's disease (AD). PARP-1 has been identified as an epigenetic regulator of plasticity and memory. Thus, we hypothesize that PARP-1 may be altered in postmortem hippocampus of individuals with AD compared to age...
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| Veröffentlicht in: | Neural plasticity. - 1998. - 2016(2016) vom: 05., Seite 8987928
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| 1. Verfasser: |
Zeng, Jianying
(VerfasserIn) |
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| Weitere Verfasser: |
Libien, Jenny,
Shaik, Fatima,
Wolk, Jason,
Hernández, A Iván |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2016
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| Zugriff auf das übergeordnete Werk: | Neural plasticity
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Chromosomal Proteins, Non-Histone
DNA, Ribosomal
fibrillarin
PARP1 protein, human
EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1 |
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