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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1111/nph.13944
|2 doi
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|a pubmed24n0863.xml
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|a (DE-627)NLM258939117
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|a (NLM)27030513
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Niehl, Annette
|e verfasserin
|4 aut
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| 245 |
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|a Double-stranded RNAs induce a pattern-triggered immune signaling pathway in plants
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.01.2018
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|a Date Revised 16.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.
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|a Pattern-triggered immunity (PTI) is a plant defense response that relies on the perception of conserved microbe- or pathogen-associated molecular patterns (MAMPs or PAMPs, respectively). Recently, it has been recognized that PTI restricts virus infection in plants; however, the nature of the viral or infection-induced PTI elicitors and the underlying signaling pathways are still unknown. As double-stranded RNAs (dsRNAs) are conserved molecular patterns associated with virus replication, we applied dsRNAs or synthetic dsRNA analogs to Arabidopsis thaliana and investigated PTI responses. We show that in vitro-generated dsRNAs, dsRNAs purified from virus-infected plants and the dsRNA analog polyinosinic-polycytidylic acid (poly(I:C)) induce typical PTI responses dependent on the co-receptor SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 1 (SERK1), but independent of dicer-like (DCL) proteins in Arabidopsis. Moreover, dsRNA treatment of Arabidopsis induces SERK1-dependent antiviral resistance. Screening of Arabidopsis wild accessions demonstrates natural variability in dsRNA sensitivity. Our findings suggest that dsRNAs represent genuine PAMPs in plants, which induce a signaling cascade involving SERK1 and a specific dsRNA receptor. The dependence of dsRNA-mediated PTI on SERK1, but not on DCLs, implies that dsRNA-mediated PTI involves membrane-associated processes and operates independently of RNA silencing. dsRNA sensitivity may represent a useful trait to increase antiviral resistance in cultivated plants
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arabidopsis
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|a RNA silencing
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|a double-stranded RNA (dsRNA)
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|a natural variation
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|a pathogen-associated molecular pattern (PAMP)
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|a pattern-triggered immunity (PTI)
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|a somatic embryogenesis receptor-like kinase
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|a virus
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| 650 |
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a Pathogen-Associated Molecular Pattern Molecules
|2 NLM
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| 650 |
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|a RNA, Double-Stranded
|2 NLM
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| 650 |
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|a Flagellin
|2 NLM
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| 650 |
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|a 12777-81-0
|2 NLM
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|a Poly I-C
|2 NLM
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| 650 |
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|a O84C90HH2L
|2 NLM
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| 700 |
1 |
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|a Wyrsch, Ines
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boller, Thomas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heinlein, Manfred
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 211(2016), 3 vom: 31. Aug., Seite 1008-19
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:211
|g year:2016
|g number:3
|g day:31
|g month:08
|g pages:1008-19
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| 856 |
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|u http://dx.doi.org/10.1111/nph.13944
|3 Volltext
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|h 1008-19
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