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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201506025
|2 doi
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|a pubmed24n1346.xml
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|a eng
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|a Ye, Yanqi
|e verfasserin
|4 aut
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|a Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery
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|c 2016
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|a Text
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|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 26.03.2018
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|a Date Revised 25.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a diabetes
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|a drug delivery
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|a microneedles
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|a pancreatic cells
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|a physiological signals
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|a Blood Glucose
|2 NLM
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|a Insulin
|2 NLM
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1 |
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|a Yu, Jicheng
|e verfasserin
|4 aut
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1 |
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|a Wang, Chao
|e verfasserin
|4 aut
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1 |
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|a Nguyen, Nhu-Y
|e verfasserin
|4 aut
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1 |
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|a Walker, Glenn M
|e verfasserin
|4 aut
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1 |
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|a Buse, John B
|e verfasserin
|4 aut
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1 |
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|a Gu, Zhen
|e verfasserin
|4 aut
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|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 28(2016), 16 vom: 15. Apr., Seite 3115-3121
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|x 1521-4095
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|g volume:28
|g year:2016
|g number:16
|g day:15
|g month:04
|g pages:3115-3121
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