Phase Transfer and Surface Functionalization of Hydrophobic Nanoparticle using Amphiphilic Poly(amino acid)

Functionalization of nanoparticles with chemical and biochemical is essential for their biomedical and other application. However, most of the high quality nanoparticles are hydrophobic in nature due to surfactant capping and their conversion into water-soluble functional nanoparticle via appropriat...

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Bibliographische Detailangaben
Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 32(2016), 11 vom: 22. März, Seite 2798-807
1. Verfasser:	Debnath, Koushik (VerfasserIn)
Weitere Verfasser:	Mandal, Kuheli, Jana, Nikhil R
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2016
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Amines Anthracenes Cadmium Compounds Ferric Compounds Peptides Phenanthrenes Selenium Compounds Sulfides mehr... Zinc Compounds ferric oxide 1K09F3G675 Fluorescamine 38183-12-9 Polyethylene Glycols 3WJQ0SDW1A 9,10-phenanthrenequinone 42L7BZ8H74 Arginine 94ZLA3W45F Dithionitrobenzoic Acid 9BZQ3U62JX cadmium selenide A7F646JC5C stearylamine FFV58UNY7O anthrone FP0FJ7K744 zinc sulfide KPS085631O


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100	1		\|a Debnath, Koushik \|e verfasserin \|4 aut
245	1	0	\|a Phase Transfer and Surface Functionalization of Hydrophobic Nanoparticle using Amphiphilic Poly(amino acid)
264		1	\|c 2016
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500			\|a Date Revised 02.12.2018
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500			\|a Citation Status MEDLINE
520			\|a Functionalization of nanoparticles with chemical and biochemical is essential for their biomedical and other application. However, most of the high quality nanoparticles are hydrophobic in nature due to surfactant capping and their conversion into water-soluble functional nanoparticle via appropriate coating and conjugation chemistry is extremely critical issue. Here we report amphiphilic poly(amino acid)-based one-pot coating and conjugation approach that can transform hydrophobic nanoparticle into water-soluble nanoparticle functionalized with primary amine, thiol, and biomolecule. We have designed amphiphilic polyaspartimide that can anchor hydrophobic nanoparticle through octadecyl groups, leaving the polar polyethylene glycol and aspartimide groups exposed outwards. The aspartimide group is then reacted with primary amine containing chemical/biomolecule with the formation of water-soluble functional nanoparticle. This approach has been extended to different hydrophobic nanoparticles and biomolecules. The present approach has advantages over existing approaches as coating and functionalization can be performed in one pot and functional nanoparticles have <12 nm hydrodynamic size, high colloidal stability, and biocompartibility. This developed approach can be used to derive biocompatible nanobioconjugates for various biomedical applications
650		4	\|a Journal Article
650		4	\|a Research Support, Non-U.S. Gov't
650		7	\|a Amines \|2 NLM
650		7	\|a Anthracenes \|2 NLM
650		7	\|a Cadmium Compounds \|2 NLM
650		7	\|a Ferric Compounds \|2 NLM
650		7	\|a Peptides \|2 NLM
650		7	\|a Phenanthrenes \|2 NLM
650		7	\|a Selenium Compounds \|2 NLM
650		7	\|a Sulfides \|2 NLM
650		7	\|a Zinc Compounds \|2 NLM
650		7	\|a ferric oxide \|2 NLM
650		7	\|a 1K09F3G675 \|2 NLM
650		7	\|a Fluorescamine \|2 NLM
650		7	\|a 38183-12-9 \|2 NLM
650		7	\|a Polyethylene Glycols \|2 NLM
650		7	\|a 3WJQ0SDW1A \|2 NLM
650		7	\|a 9,10-phenanthrenequinone \|2 NLM
650		7	\|a 42L7BZ8H74 \|2 NLM
650		7	\|a Arginine \|2 NLM
650		7	\|a 94ZLA3W45F \|2 NLM
650		7	\|a Dithionitrobenzoic Acid \|2 NLM
650		7	\|a 9BZQ3U62JX \|2 NLM
650		7	\|a cadmium selenide \|2 NLM
650		7	\|a A7F646JC5C \|2 NLM
650		7	\|a stearylamine \|2 NLM
650		7	\|a FFV58UNY7O \|2 NLM
650		7	\|a anthrone \|2 NLM
650		7	\|a FP0FJ7K744 \|2 NLM
650		7	\|a zinc sulfide \|2 NLM
650		7	\|a KPS085631O \|2 NLM
700	1		\|a Mandal, Kuheli \|e verfasserin \|4 aut
700	1		\|a Jana, Nikhil R \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Langmuir : the ACS journal of surfaces and colloids \|d 1992 \|g 32(2016), 11 vom: 22. März, Seite 2798-807 \|w (DE-627)NLM098181009 \|x 1520-5827 \|7 nnns
773	1	8	\|g volume:32 \|g year:2016 \|g number:11 \|g day:22 \|g month:03 \|g pages:2798-807
856	4	0	\|u http://dx.doi.org/10.1021/acs.langmuir.6b00282 \|3 Volltext
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