|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM257682317 |
| 003 |
DE-627 |
| 005 |
20231224183344.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2016 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2016.02.005
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0858.xml
|
| 035 |
|
|
|a (DE-627)NLM257682317
|
| 035 |
|
|
|a (NLM)26898311
|
| 035 |
|
|
|a (PII)S1521-6616(16)30021-3
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Ajendra, Jesuthas
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis
|
| 264 |
|
1 |
|c 2016
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 18.07.2016
|
| 500 |
|
|
|a Date Revised 07.03.2016
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2016 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Animal studies demonstrated that administration of helminth products can protect from autoimmune diseases. However, the success of such administrations is limited in the case of type 1 diabetes, as protection is only provided if the administration is started before the development of insulitis. In this study we investigated whether inclusion of helminth antigen administrations to an antigen-specific treatment with proinsulin improves the protective effect by triggering non-specific regulatory immune responses. Using a combination therapy of intraperitoneal Litomosoides sigmodontis antigen and intranasal pro-insulin, onset of diabetes was prevented in NOD mice after insulitis started, while either administration alone failed to protect. This protection was associated with an increased frequency of regulatory T cells within the pancreatic lymph nodes and a reduced inflammation of the pancreatic islets. This suggests that inclusion of helminth antigens improve the protective effect provided by antigen-specific therapies and represent a new potential therapeutic approach against autoimmune diseases
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Filariae
|
| 650 |
|
4 |
|a Helminth
|
| 650 |
|
4 |
|a Litomosoides sigmodontis
|
| 650 |
|
4 |
|a Proinsulin
|
| 650 |
|
4 |
|a Regulatory T cells
|
| 650 |
|
4 |
|a Type 1 diabetes
|
| 650 |
|
7 |
|a Antigens, Helminth
|2 NLM
|
| 650 |
|
7 |
|a Insulin
|2 NLM
|
| 650 |
|
7 |
|a Proinsulin
|2 NLM
|
| 650 |
|
7 |
|a 9035-68-1
|2 NLM
|
| 700 |
1 |
|
|a Berbudi, Afiat
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hoerauf, Achim
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hübner, Marc P
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 164(2016) vom: 22. März, Seite 119-22
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:164
|g year:2016
|g day:22
|g month:03
|g pages:119-22
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2016.02.005
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 164
|j 2016
|b 22
|c 03
|h 119-22
|