Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis

Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis

Copyright © 2016 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 164(2016) vom: 04. März, Seite 114-8
1. Verfasser: Vadasz, Zahava (VerfasserIn)
Weitere Verfasser: Goldeberg, Yair, Halasz, Katty, Rosner, Itzhak, Valesini, Guido, Conti, Fabrizio, Perricone, Carlo, Sthoeger, Zev, Bezalel, Shira Rosenberg, Tzioufas, Athanasios G, Levin, Nancy Agmon, Shoenfeld, Yehuda, Toubi, Elias
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Nephritis SLE SLEDAI Soluble CD72 anti-cardiolipin antibody anti-dsDNA antibody Antibodies, Antinuclear Antigens, CD Antigens, Differentiation, B-Lymphocyte mehr... Biomarkers CD100 antigen CD72 protein, human Semaphorins
Beschreibung
Zusammenfassung:Copyright © 2016 Elsevier Inc. All rights reserved.
INTRODUCTION: B cell receptor (BCR) -mediated signals are enhanced when CD72 expression is deficient on B cells in autoimmune diseases. The significance of soluble CD72 (sCD72) has not been elucidated
METHODS: Soluble CD72 was analyzed in the serum of 159 SLE patients, 40 rheumatoid arthritis (RA) patients, and 100 healthy individuals. Correlations between sCD72 and SLE disease activity (SLEDAI) were assessed
RESULTS: Soluble CD72 was found increased in SLE patients, when compared to both RA patients and healthy individuals (20.2 ± 1.2 ng/ml; 10.6 ± 4.6 ng/ml and 7.2 ± 3.3 ng/ml; p < 0.001). Soluble CD72 level was significantly higher in SLE patients with renal involvement than in patients without (31.8 ± 2.3 ng/ml vs 13.9 ± 0.9 ng/ml; p < 0.001) and also with the presence of auto-antibodies
CONCLUSION: Soluble CD72 is significantly increased in SLE patients mainly in those with renal involvement. Increased sCD72 may become a potential biomarker for renal involvement in SLE
Beschreibung:Date Completed 18.07.2016
Date Revised 07.03.2016
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2016.02.004