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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1155/2016/2726745
|2 doi
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|a pubmed25n0857.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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|a Gómez-Chacón, Beatriz
|e verfasserin
|4 aut
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|a Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 04.11.2016
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|a Date Revised 05.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Interactions between GluR2 and N-ethylmaleimide-sensitive factor (NSF) mediate AMPA receptors trafficking. This might be linked with molecular mechanisms related with memory formation. Previous research has shown basolateral amygdala (BLA) dependent activity changes in the perirhinal cortex (PRh) during the formation of taste memory. In the present experiments we investigate both the behavioral performance and the expression profile of NSF and GluR2 genes in several brain areas, including PRh, BLA, and hippocampus. Twenty-one naïve male Wistar rats were exposed to a saccharin solution (0.4%) during the first (novel), the second (Familiar I), and the sixth presentation (Familiar II). Total RNA was extracted and gene expression was measured by quantitative PCR (qPCR) using TaqMan gene expression assays. In addition the expression of the synaptic plasticity related immediate early genes, Homer 1 and Narp, was also assessed. We have found increased expression of NSF gene in BLA and PRh in Group Familiar I in comparison with Familiar II. No changes in the expression of GluR2, Homer 1, and Narp genes were found. The results suggest the relevance of a potential network in the temporal lobe for taste recognition memory and open new possibilities for understanding the molecular mechanisms mediating the impact of sensory experience on brain circuit function
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Carrier Proteins
|2 NLM
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|a Homer Scaffolding Proteins
|2 NLM
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|a Nerve Tissue Proteins
|2 NLM
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|a Receptors, AMPA
|2 NLM
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|a neuronal pentraxin
|2 NLM
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|a C-Reactive Protein
|2 NLM
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|a 9007-41-4
|2 NLM
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| 650 |
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|a N-Ethylmaleimide-Sensitive Proteins
|2 NLM
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| 650 |
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|a EC 3.6.4.6
|2 NLM
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| 650 |
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|a Nsf protein, rat
|2 NLM
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| 650 |
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|a EC 3.6.4.6
|2 NLM
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| 650 |
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|a glutamate receptor ionotropic, AMPA 2
|2 NLM
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| 650 |
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|a P6W5IXV8V9
|2 NLM
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| 700 |
1 |
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|a Gámiz, Fernando
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Foster, Thomas C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gallo, Milagros
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2016(2016) vom: 26., Seite 2726745
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnns
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| 773 |
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|g volume:2016
|g year:2016
|g day:26
|g pages:2726745
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|u http://dx.doi.org/10.1155/2016/2726745
|3 Volltext
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|h 2726745
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