Early BAFF receptor blockade mitigates murine Sjögren's syndrome Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction

Early BAFF receptor blockade mitigates murine Sjögren's syndrome : Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction

Copyright © 2016 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 164(2016) vom: 05. März, Seite 85-94
1. Verfasser: Sharma, Arjun (VerfasserIn)
Weitere Verfasser: Kiripolsky, Jeremy, Klimatcheva, Ekaterina, Howell, Alan, Fereidouni, Farzad, Levenson, Richard, Rothstein, Thomas L, Kramer, Jill M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Autoantibody BAFF receptor CXCL13 Salivary hypofunction Sialadenitis Sjögren's syndrome Antibodies mehr... B-Cell Activation Factor Receptor Chemokine CXCL13 Cxcl13 protein, mouse Tnfrsf13c protein, mouse
Beschreibung
Zusammenfassung:Copyright © 2016 Elsevier Inc. All rights reserved.
Sjögren's syndrome (SS) is a debilitating autoimmune disease. Patients with SS may develop xerostomia. This process is progressive, and there are no therapeutics that target disease etiology. We hypothesized BAFF receptor (BAFFR) blockade would mitigate SS disease development, and neutralization of CXCL13 and BAFF signaling would be more efficacious than BAFFR blockade alone. We treated NOD/ShiLtJ SS mice with soluble BAFF receptor (BAFFR-Fc) or anti-CXCL13/BAFFR-Fc in combination, prior to the development of clinical disease. Our results show treatment with BAFFR-Fc reduced peripheral B cell numbers and decreased sialadenitis. In addition, this treatment reduced total serum immunoglobulin as well as IgG and IgM specific anti-nuclear autoantibodies. NOD/ShiLtJ mice treated with BAFFR-Fc and anti-CXCL13 antibody were protected from salivary deficits. Results from this study suggest blockade of CXCL13 and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with SS
Beschreibung:Date Completed 18.07.2016
Date Revised 13.11.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2016.01.015