Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 164(2016) vom: 15. März, Seite 95-105
1. Verfasser:	Torrentes-Carvalho, Amanda (VerfasserIn)
Weitere Verfasser:	Hottz, Eugênio Damaceno, Marinho, Cintia Ferreira, da Silva, Jéssica Badolato-Corrêa, Pinto, Luzia Maria de Oliveira, Fialho, Luciana Gomes, Bozza, Fernando Augusto, Cunha, Rivaldo Venâncio, Damasco, Paulo Vieira, Kubelka, Claire Fernandes, de Azeredo, Elzinandes Leal
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2016
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Coinfection Cytokines Dengue HIV Lymphocytes

Beschreibung
Zusammenfassung:	Copyright © 2016 Elsevier Inc. All rights reserved. The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV
Beschreibung:	Date Completed 18.07.2016 Date Revised 07.03.2016 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2016.01.005