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231224s2016 xx |||||o 00| ||eng c |
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7 |
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|a 10.1021/acs.langmuir.5b04166
|2 doi
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|a pubmed24n0856.xml
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|a (NLM)26818564
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a De León, A S
|e verfasserin
|4 aut
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| 245 |
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|a Immobilization of Stimuli-Responsive Nanogels onto Honeycomb Porous Surfaces and Controlled Release of Proteins
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 13.12.2016
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In this article, we describe the formation of functional honeycomb-like porous surfaces fabricated by the breath figures technique using blends of either amino-terminated poly(styrene) or a poly(styrene)-b-poly(acrylic acid) block copolymer with homopoly(styrene). Thus, the porous interfaces exhibited either amino or acid groups selectively located inside of the holes, which were subsequently employed to anchor stimuli-responsive nanogels by electrostatic interactions. These nanogels were prepared from poly(N-isopropylacrylamide) (PNIPAM) cross-linked with dendritic polyglycerol (dPG) and semi-interpenetrated with either 2-(dimethylamino)ethyl methacrylate (DMAEMA) or 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) to produce positively and negatively charged nanogel surfaces, respectively. The immobilization of these semi-interpenetrated networks onto the surfaces allowed us to have unique stimuli-responsive surfaces with both controlled topography and composition. More interestingly, the surfaces exhibited stimuli-responsive behavior by variations on the pH or temperature. Finally, the surfaces were evaluated regarding their capacity to induce a thermally triggered protein release at temperatures above the cloud point temperature (T(cp)) of the nanogels
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Delayed-Action Preparations
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|a Drug Carriers
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|a Gels
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|a Polymers
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|a Serum Albumin, Bovine
|2 NLM
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|a 27432CM55Q
|2 NLM
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|a Molina, M
|e verfasserin
|4 aut
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|a Wedepohl, S
|e verfasserin
|4 aut
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|a Muñoz-Bonilla, A
|e verfasserin
|4 aut
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|a Rodríguez-Hernández, J
|e verfasserin
|4 aut
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| 700 |
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|a Calderón, M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 32(2016), 7 vom: 23. Feb., Seite 1854-62
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:32
|g year:2016
|g number:7
|g day:23
|g month:02
|g pages:1854-62
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|u http://dx.doi.org/10.1021/acs.langmuir.5b04166
|3 Volltext
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