Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity

Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity

© 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 210(2016), 2 vom: 14. Apr., Seite 627-42
1. Verfasser: Postma, Jelle (VerfasserIn)
Weitere Verfasser: Liebrand, Thomas W H, Bi, Guozhi, Evrard, Alexandre, Bye, Ruby R, Mbengue, Malick, Kuhn, Hannah, Joosten, Matthieu H A J, Robatzek, Silke
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Avr4 effector BAK1/SERK3 Cf-4 receptor-like protein (RLP) SUPPRESSOR OF BIR1 (SOBIR1) immunity receptor endocytosis subcellular trafficking Arabidopsis Proteins mehr... Fungal Proteins Ligands Receptors, Cell Surface BAK1 protein, Arabidopsis EC 2.7.1.- Protein Serine-Threonine Kinases EC 2.7.11.1
LEADER 01000caa a22002652 4500
001 NLM25643722X
003 DE-627
005 20231227125319.0
007 cr uuu---uuuuu
008 231224s2016 xx |||||o 00| ||eng c
024 7 |a 10.1111/nph.13802  |2 doi 
028 5 2 |a pubmed24n1223.xml 
035 |a (DE-627)NLM25643722X 
035 |a (NLM)26765243 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Postma, Jelle  |e verfasserin  |4 aut 
245 1 0 |a Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity 
264 1 |c 2016 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 13.12.2016 
500 |a Date Revised 13.12.2023 
500 |a published: Print-Electronic 
500 |a GENBANK: AY436765 
500 |a Citation Status MEDLINE 
520 |a © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust. 
520 |a The first layer of plant immunity is activated by cell surface receptor-like kinases (RLKs) and proteins (RLPs) that detect infectious pathogens. Constitutive interaction with the SUPPRESSOR OF BIR1 (SOBIR1) RLK contributes to RLP stability and kinase activity. As RLK activation requires transphosphorylation with a second associated RLK, it remains elusive how RLPs initiate downstream signaling. We employed live-cell imaging, gene silencing and coimmunoprecipitation to investigate the requirement of associated kinases for functioning and ligand-induced subcellular trafficking of Cf RLPs that mediate immunity of tomato against Cladosporium fulvum. Our research shows that after elicitation with matching effector ligands Avr4 and Avr9, BRI1-ASSOCIATED KINASE 1/SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 (BAK1/SERK3) associates with Cf-4 and Cf-9. BAK1/SERK3 is required for the effector-triggered hypersensitive response and resistance of tomato against C. fulvum. Furthermore, Cf-4 interacts with SOBIR1 at the plasma membrane and is recruited to late endosomes upon Avr4 trigger, also depending on BAK1/SERK3. These observations indicate that RLP-mediated resistance and endocytosis require ligand-induced recruitment of BAK1/SERK3, reminiscent of BAK1/SERK3 interaction and subcellular fate of the FLAGELLIN SENSING 2 (FLS2) RLK. This reveals that diverse classes of cell surface immune receptors share common requirements for initiation of resistance and endocytosis 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Avr4 effector 
650 4 |a BAK1/SERK3 
650 4 |a Cf-4 receptor-like protein (RLP) 
650 4 |a SUPPRESSOR OF BIR1 (SOBIR1) 
650 4 |a immunity 
650 4 |a receptor endocytosis 
650 4 |a subcellular trafficking 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a Fungal Proteins  |2 NLM 
650 7 |a Ligands  |2 NLM 
650 7 |a Receptors, Cell Surface  |2 NLM 
650 7 |a BAK1 protein, Arabidopsis  |2 NLM 
650 7 |a EC 2.7.1.-  |2 NLM 
650 7 |a Protein Serine-Threonine Kinases  |2 NLM 
650 7 |a EC 2.7.11.1  |2 NLM 
700 1 |a Liebrand, Thomas W H  |e verfasserin  |4 aut 
700 1 |a Bi, Guozhi  |e verfasserin  |4 aut 
700 1 |a Evrard, Alexandre  |e verfasserin  |4 aut 
700 1 |a Bye, Ruby R  |e verfasserin  |4 aut 
700 1 |a Mbengue, Malick  |e verfasserin  |4 aut 
700 1 |a Kuhn, Hannah  |e verfasserin  |4 aut 
700 1 |a Joosten, Matthieu H A J  |e verfasserin  |4 aut 
700 1 |a Robatzek, Silke  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t The New phytologist  |d 1979  |g 210(2016), 2 vom: 14. Apr., Seite 627-42  |w (DE-627)NLM09818248X  |x 1469-8137  |7 nnns 
773 1 8 |g volume:210  |g year:2016  |g number:2  |g day:14  |g month:04  |g pages:627-42 
856 4 0 |u http://dx.doi.org/10.1111/nph.13802  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 210  |j 2016  |e 2  |b 14  |c 04  |h 627-42