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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1107/S1600577515018561
|2 doi
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|a pubmed24n0852.xml
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|a eng
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| 100 |
1 |
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|a Nemoz, Christian
|e verfasserin
|4 aut
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| 245 |
1 |
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|a In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy
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| 264 |
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 26.09.2016
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|a Date Revised 24.12.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of ∼20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a alignment procedure
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|a brain tumors
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| 650 |
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|a pink-beam imaging
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| 650 |
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4 |
|a synchrotron microbeam radiation therapy
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| 700 |
1 |
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|a Kibleur, Astrid
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hyacinthe, Jean Noël
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Berruyer, Gilles
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brochard, Thierry
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bräuer-Krisch, Elke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Le Duc, Géraldine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brun, Emmanuel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elleaume, Hélène
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Serduc, Raphaël
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 23(2016), 1 vom: 25. Jan., Seite 339-43
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
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| 773 |
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|g volume:23
|g year:2016
|g number:1
|g day:25
|g month:01
|g pages:339-43
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|u http://dx.doi.org/10.1107/S1600577515018561
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