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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.11.008
|2 doi
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|a pubmed24n0850.xml
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|a (NLM)26628192
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|a (PII)S1521-6616(15)30065-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
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|a Serrano, Carmen J
|e verfasserin
|4 aut
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| 245 |
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|a Transcriptional profiles discriminate patients with pulmonary tuberculosis from non-tuberculous individuals depending on the presence of non-insulin diabetes mellitus
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.05.2016
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|a Date Revised 01.01.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Our objective was to identify transcriptional biomarkers in peripheral blood mononuclear cells (PBMC) that discriminate individuals with latent tuberculosis infection (LTBI) from those with pulmonary tuberculosis (PTB) in subjects with non-insulin-dependent diabetes mellitus (NIDDM) and in individuals without NIDDM. Using gene expression microarrays we identified differentially expressed genes from lungs of mice infected with Mycobacterium tuberculosis (Mtb) or a mutant (ΔsigH) representing a non-inflammatory model. Genes expressed in blood, with inflammatory related functions were evaluated in humans by RT-qPCR. NCF1 and ORM transcripts have the better discriminatory capacity to identify PTB subjects from LTBI and non-infected controls (NICs) independently of the presence of NIDDM. The sequential evaluation of the mRNA levels of NCF1 and ORM as multiple diagnostic tests showed 95% Sensitivity (Se) and 80% Specificity (Sp). In addition, FPR2 promises to be a good biomarker for the PTB detection in subjects with NIDDM (Se=100%; Sp=90%)
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| 650 |
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Biomarkers
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| 650 |
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4 |
|a Diabetes
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| 650 |
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|a Transcriptional profile
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| 650 |
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4 |
|a Tuberculosis
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| 650 |
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|a Biomarkers
|2 NLM
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| 700 |
1 |
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|a Cuevas-Córdoba, Betzaida
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Macías-Segura, Noé
|e verfasserin
|4 aut
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| 700 |
1 |
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|a González-Curiel, Rosa Angélica
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martínez-Balderas, Víctor Yordani
|e verfasserin
|4 aut
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| 700 |
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|a Enciso-Moreno, Leonor
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Small, Peter
|e verfasserin
|4 aut
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| 700 |
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|a Hernández-Pando, Rogelio
|e verfasserin
|4 aut
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| 700 |
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|a Enciso-Moreno, José Antonio
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 162(2016) vom: 01. Jan., Seite 107-17
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:162
|g year:2016
|g day:01
|g month:01
|g pages:107-17
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.11.008
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