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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-015-1589-3
|2 doi
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|a pubmed24n0849.xml
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|a (DE-627)NLM254834159
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|a (NLM)26589948
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Alimba, Chibuisi G
|e verfasserin
|4 aut
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| 245 |
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|a In vivo micronucleus test in the assessment of cytogenotoxicity of landfill leachates in three animal models from various ecological habitats
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 01.11.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The in vivo micronucleus (MN) test, a standard test for the genotoxicity screening of xenobiotics, was used to evaluate the cytotoxic and genotoxic activities of landfill leachates in Clarias gariepinus, Coturnix coturnix japonica and Rattus norvegicus. These organisms were exposed to various sub-lethal concentrations (1-50%) of Olusosun and Aba Eku landfill leachates. At post exposure, peripheral erythrocytes from catfish and quail, and bone marrow cells of quail and rat were subjected to MN analysis following standard protocols. The leachates induced significant increase in MN formation and total nuclear abnormalities (NAs) in the peripheral erythrocytes of catfish and quail. NAs occurred in the order; BN > BL > LB > NT in the catfish and BN > BudN > TLN > TN in quail. There was significant increase in MN formation in the bone marrow cells of quail, and micronucleated polychromatic erythrocytes and micronucleated normochromatic erythrocytes formation in the bone marrow of rats. The concentration dependent significant (p < 0.05) decrease in the PCE/NCE ratio in the bone marrow of the leachate treated rats suggest alterations in the bone marrow cell proliferation, leading to the suppression of immature erythrocytes (PCE). MN induction showed positive corrections with leachate concentrations in the test organisms; and it increased with exposure duration in the catfish. Indiscriminate disposal of solid waste generates leachates containing multiple xenobiotics that are capable of increasing genomic instability among vertebrates inhabiting various ecological habitats
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|a Journal Article
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|a Clarias gariepinus
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| 650 |
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|a Coturnix coturnix japonica
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| 650 |
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|a Cytotoxicity
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| 650 |
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|a Genotoxicity
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| 650 |
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|a Landfill leachates
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| 650 |
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4 |
|a Micronucleus assay
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| 650 |
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4 |
|a Rattus norvegicus
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| 650 |
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|a Cytotoxins
|2 NLM
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| 650 |
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|a Mutagens
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 700 |
1 |
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|a Bakare, Adekunle A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 25(2016), 2 vom: 08. März, Seite 310-9
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:25
|g year:2016
|g number:2
|g day:08
|g month:03
|g pages:310-9
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| 856 |
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|u http://dx.doi.org/10.1007/s10646-015-1589-3
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