Dissecting quantitative trait variation in the resequencing era : complementarity of bi-parental, multi-parental and association panels

Published by Elsevier Ireland Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Plant science : an international journal of experimental plant biology. - 1985. - 242(2016) vom: 13. Jan., Seite 120-130
1. Verfasser: Pascual, Laura (VerfasserIn)
Weitere Verfasser: Albert, Elise, Sauvage, Christopher, Duangjit, Janejira, Bouchet, Jean-Paul, Bitton, Frédérique, Desplat, Nelly, Brunel, Dominique, Le Paslier, Marie-Christine, Ranc, Nicolas, Bruguier, Laure, Chauchard, Betty, Verschave, Philippe, Causse, Mathilde
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Plant science : an international journal of experimental plant biology
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Fruit quality Genome-wide association QTL mapping Resequencing Tomato
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520 |a Quantitative trait loci (QTL) have been identified using traditional linkage mapping and positional cloning identified several QTLs. However linkage mapping is limited to the analysis of traits differing between two lines and the impact of the genetic background on QTL effect has been underlined. Genome-wide association studies (GWAs) were proposed to circumvent these limitations. In tomato, we have shown that GWAs is possible, using the admixed nature of cherry tomato genomes that reduces the impact of population structure. Nevertheless, GWAs success might be limited due to the low decay of linkage disequilibrium, which varies along the genome in this species. Multi-parent advanced generation intercross (MAGIC) populations offer an alternative to traditional linkage and GWAs by increasing the precision of QTL mapping. We have developed a MAGIC population by crossing eight tomato lines whose genomes were resequenced. We showed the potential of the MAGIC population when coupled with whole genome sequencing to detect candidate single nucleotide polymorphisms (SNPs) underlying the QTLs. QTLs for fruit quality traits were mapped and related to the variations detected at the genome sequence and expression levels. The advantages and limitations of the three types of population, in the context of the available genome sequence and resequencing facilities, are discussed 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Fruit quality 
650 4 |a Genome-wide association 
650 4 |a QTL mapping 
650 4 |a Resequencing 
650 4 |a Tomato 
700 1 |a Albert, Elise  |e verfasserin  |4 aut 
700 1 |a Sauvage, Christopher  |e verfasserin  |4 aut 
700 1 |a Duangjit, Janejira  |e verfasserin  |4 aut 
700 1 |a Bouchet, Jean-Paul  |e verfasserin  |4 aut 
700 1 |a Bitton, Frédérique  |e verfasserin  |4 aut 
700 1 |a Desplat, Nelly  |e verfasserin  |4 aut 
700 1 |a Brunel, Dominique  |e verfasserin  |4 aut 
700 1 |a Le Paslier, Marie-Christine  |e verfasserin  |4 aut 
700 1 |a Ranc, Nicolas  |e verfasserin  |4 aut 
700 1 |a Bruguier, Laure  |e verfasserin  |4 aut 
700 1 |a Chauchard, Betty  |e verfasserin  |4 aut 
700 1 |a Verschave, Philippe  |e verfasserin  |4 aut 
700 1 |a Causse, Mathilde  |e verfasserin  |4 aut 
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