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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b03221
|2 doi
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|a pubmed24n0848.xml
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|a eng
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| 100 |
1 |
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|a Molina, Emilie
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Drug-Polymer Electrostatic Complexes as New Structuring Agents for the Formation of Drug-Loaded Ordered Mesoporous Silica
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|c 2015
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 16.09.2016
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behavior was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors, and this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multistep processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials
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|a Research Support, Non-U.S. Gov't
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|a Drug Carriers
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|a Polymers
|2 NLM
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|a Polyethylene Glycols
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|a 3WJQ0SDW1A
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|a Silicon Dioxide
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|a 7631-86-9
|2 NLM
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| 700 |
1 |
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|a Warnant, Jérôme
|e verfasserin
|4 aut
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|a Mathonnat, Mélody
|e verfasserin
|4 aut
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|a Bathfield, Maël
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|a In, Martin
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|a Laurencin, Danielle
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|a Jérôme, Christine
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|a Lacroix-Desmazes, Patrick
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|4 aut
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| 700 |
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|a Marcotte, Nathalie
|e verfasserin
|4 aut
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| 700 |
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|a Gérardin, Corine
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
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|g 31(2015), 47 vom: 01. Dez., Seite 12839-44
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|g volume:31
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|g month:12
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