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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b03557
|2 doi
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|a eng
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|a Carter, Matthew C D
|e verfasserin
|4 aut
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|a Synthetic Mimics of Bacterial Lipid A Trigger Optical Transitions in Liquid Crystal Microdroplets at Ultralow Picogram-per-Milliliter Concentrations
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 16.09.2016
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We report synthetic six-tailed mimics of the bacterial glycolipid Lipid A that trigger changes in the internal ordering of water-dispersed liquid crystal (LC) microdroplets at ultralow (picogram-per-milliliter) concentrations. These molecules represent the first class of synthetic amphiphiles to mimic the ability of Lipid A and bacterial endotoxins to trigger optical responses in LC droplets at these ultralow concentrations. This behavior stands in contrast to all previously reported synthetic surfactants and lipids, which require near-complete monolayer coverage at the LC droplet surface to trigger ordering transitions. Surface-pressure measurements and SAXS experiments reveal these six-tailed synthetic amphiphiles to mimic key aspects of the self-assembly of Lipid A at aqueous interfaces and in solution. These and other results suggest that these amphiphiles trigger orientational transitions at ultralow concentrations through a unique mechanism that is similar to that of Lipid A and involves formation of inverted self-associated nanostructures at topological defects in the LC droplets
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Lipid A
|2 NLM
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|a Miller, Daniel S
|e verfasserin
|4 aut
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|a Jennings, James
|e verfasserin
|4 aut
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|a Wang, Xiaoguang
|e verfasserin
|4 aut
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|a Mahanthappa, Mahesh K
|e verfasserin
|4 aut
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|a Abbott, Nicholas L
|e verfasserin
|4 aut
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|a Lynn, David M
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 31(2015), 47 vom: 01. Dez., Seite 12850-5
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:31
|g year:2015
|g number:47
|g day:01
|g month:12
|g pages:12850-5
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|u http://dx.doi.org/10.1021/acs.langmuir.5b03557
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