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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.12416
|2 doi
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|a pubmed25n0847.xml
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|a (NLM)26525310
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Feng, J-B
|e verfasserin
|4 aut
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|a Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 26.04.2017
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2015 John Wiley & Sons Ltd.
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|a Pharmacokinetics and elimination of florfenicol and florfenicol amine in grouper held in sea water at 23.3 ± 0.8 °C were studied using HPLC method after they were given a single peroral dose of florfenicol at 24 mg kg(-1) body weight. Florfenicol was rapidly absorbed from intestine and distributed extensively to all the tissues examined. The maximum concentrations (Cmax , μg g(-1) or μg mL(-1) ) in plasma and tissues were observed at 2-6 h (the time to reach maximum concentration, Tmax ) except for bile (Tmax = 24 h) and were in the order of intestine (52.02 ± 25.07) > bile (49.41 ± 28.16) > gill (45.12 ± 11.10) > plasma (28.28 ± 5.43) > liver (21.97 ± 12.08) > muscle (21.63 ± 6.12) > kidney (20.88 ± 11.28) > skin (19.10 ± 5.88). The drug distribution level was higher in plasma than in extravascular tissues except for bile, based on the ratios of the area under concentration-time curve between tissue and plasma (AUCtissue/plasma ). The elimination of florfenicol was rapid in fish, and the corresponding half-lives (T1/2β ) in the order of magnitude were bile (13.92 h) > muscle or liver (12.31 h) > skin (11.77 h) > plasma (11.57) > gill (11.04 h) > intestine (10.55 h) > kidney (10.05 h). The delayed Tmax , lower Cmax and longer T1/2β for florfenicol amine compared with florfenicol were measured in grouper
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|a Journal Article
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|a distribution
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|a elimination
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|a florfenicol
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|a Anti-Bacterial Agents
|2 NLM
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|a florfenicol amine
|2 NLM
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|a 76639-93-5
|2 NLM
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| 650 |
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|a florfenicol
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|a 9J97307Y1H
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| 700 |
1 |
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|a Huang, D-R
|e verfasserin
|4 aut
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| 700 |
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|a Zhong, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, J-D
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 39(2016), 7 vom: 15. Juli, Seite 833-43
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
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|g volume:39
|g year:2016
|g number:7
|g day:15
|g month:07
|g pages:833-43
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|u http://dx.doi.org/10.1111/jfd.12416
|3 Volltext
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