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cr uuu---uuuuu |
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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.10.007
|2 doi
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|a pubmed25n0847.xml
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|a (DE-627)NLM254206115
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|a (NLM)26521071
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|a (PII)S1521-6616(15)30055-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chen, Ching-I
|e verfasserin
|4 aut
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| 245 |
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|a Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the bone marrow of normal and lupus mice
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.05.2016
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|a Date Revised 03.01.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a We studied effects of early and late apoptotic (necroptotic) cell products, related damage associated alarmins and TLR agonists, on hematopoietic stem and progenitor cells (HSPC). Surprisingly, normal HSPC themselves produced IL-17 and IL-21 after 1½days of stimulation, and the best stimulators were TLR 7/8 agonist; HMGB1-DNA; TLR 9 agonist, and necroptotic B cells. The stimulated HSPC expressed additional cytokines/mediators, directly causing rapid expansion of IL-17(+) memory CD4 T (Th17), and CD8 T (Tc17) cells, and antigen-experienced IL-17(+) T cells with "naïve" phenotype. In lupus marrow, HSPC were spontaneously pre-stimulated by endogenous signals to produce IL-17 and IL-21. In contrast to HSPC, megakaryocyte progenitors (MKP) did not produce IL-17, and unlike HSPC, they could process and present particulate apoptotic autoantigens to augment autoimmune memory Th17 response. Thus abnormally stimulated primitive hematopoietic progenitors augment expansion of IL-17 producing immune and autoimmune memory T cells in the bone marrow, which may affect central tolerance
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Apoptosis
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|a Bone marrow
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|a Cytokines
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|a Hematopoietic progenitors
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|a Lupus
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|a Memory Th17/Tc17 cells
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|a TLR signals
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|a CD4 Antigens
|2 NLM
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| 650 |
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|a CD8 Antigens
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a IL17A protein, human
|2 NLM
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| 650 |
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|a Interleukin-17
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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| 650 |
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|a Toll-Like Receptors
|2 NLM
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| 650 |
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|a Interleukin-21
|2 NLM
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| 650 |
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|a MKM3CA6LT1
|2 NLM
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| 700 |
1 |
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|a Zhang, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Datta, Syamal K
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 162(2016) vom: 15. Jan., Seite 9-26
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:162
|g year:2016
|g day:15
|g month:01
|g pages:9-26
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.10.007
|3 Volltext
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