|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM253855837 |
| 003 |
DE-627 |
| 005 |
20231224171122.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2015 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/jcc.24210
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0846.xml
|
| 035 |
|
|
|a (DE-627)NLM253855837
|
| 035 |
|
|
|a (NLM)26484844
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Fan, Guo-Liang
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a DSPMP
|b Discriminating secretory proteins of malaria parasite by hybridizing different descriptors of Chou's pseudo amino acid patterns
|
| 264 |
|
1 |
|c 2015
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 04.05.2016
|
| 500 |
|
|
|a Date Revised 28.10.2015
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2015 Wiley Periodicals, Inc.
|
| 520 |
|
|
|a Identification of the proteins secreted by the malaria parasite is important for developing effective drugs and vaccines against infection. Therefore, we developed an improved predictor called "DSPMP" (Discriminating Secretory Proteins of Malaria Parasite) to identify the secretory proteins of the malaria parasite by integrating several vector features using support vector machine-based methods. DSPMP achieved an overall predictive accuracy of 98.61%, which is superior to that of the existing predictors in this field. We show that our method is capable of identifying the secretory proteins of the malaria parasite and found that the amino acid composition for buried and exposed sequences, denoted by AAC(b/e), was the most important feature for constructing the predictor. This article not only introduces a novel method for detecting the important features of sample proteins related to the malaria parasite but also provides a useful tool for tackling general protein-related problems. The DSPMP webserver is freely available at http://202.207.14.87:8032/fuwu/DSPMP/index.asp
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a acid dissociation constant
|
| 650 |
|
4 |
|a chemical shift
|
| 650 |
|
4 |
|a protein stickiness
|
| 650 |
|
4 |
|a secretory proteins
|
| 650 |
|
4 |
|a support vector machine
|
| 650 |
|
7 |
|a Amino Acids
|2 NLM
|
| 650 |
|
7 |
|a Protozoan Proteins
|2 NLM
|
| 700 |
1 |
|
|a Zhang, Xiao-Yan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Yan-Ling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Nang, Yi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Hui
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Journal of computational chemistry
|d 1984
|g 36(2015), 31 vom: 05. Dez., Seite 2317-27
|w (DE-627)NLM098138448
|x 1096-987X
|7 nnns
|
| 773 |
1 |
8 |
|g volume:36
|g year:2015
|g number:31
|g day:05
|g month:12
|g pages:2317-27
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/jcc.24210
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 36
|j 2015
|e 31
|b 05
|c 12
|h 2317-27
|