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231224s2015 xx |||||o 00| ||eng c |
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|a 10.3928/23258160-20151008-02
|2 doi
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|a pubmed24n0845.xml
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|a (NLM)26469229
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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1 |
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|a Dansingani, Kunal K
|e verfasserin
|4 aut
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|a Optical Coherence Tomography Angiography Reveals Mature, Tangled Vascular Networks in Eyes With Neovascular Age-Related Macular Degeneration Showing Resistance to Geographic Atrophy
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 09.05.2016
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|a Date Revised 17.03.2022
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright 2015, SLACK Incorporated.
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|a BACKGROUND AND OBJECTIVE: To demonstrate a vascular pattern seen on optical coherence tomography angiography (OCTA) that appears to correlate with reduced rates of geographic atrophy (GA) in eyes receiving long-term anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD)
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|a PATIENTS AND METHODS: Non-consecutive, retrospective cohort study. Patients were included if they had received more than 50 anti-VEGF injections during a period of at least 4 years for neovascular AMD in at least one eye, with absence or minimal progression of GA. Clinical charts and imaging were reviewed retrospectively; study eyes underwent OCTA
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|a RESULTS: Nine eyes of eight patients were included. Mean age was 82 years, and mean follow-up of study eyes 9.1 years; study eyes received a mean of 65.8 injections. OCTA revealed tangled networks of neovessels associated with type 1 lesions
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|a CONCLUSION: With prolonged anti-VEGF treatment, GA appears to occur less commonly in eyes with type 1 neovascularization. OCTA shows mature tangled vessels with substantial flow within type 1 lesions. Mature, tangled networks may be associated with a decreased likelihood of developing GA despite the presence of choriocapillaris atrophy
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Angiogenesis Inhibitors
|2 NLM
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|a VEGFA protein, human
|2 NLM
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| 650 |
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|a Vascular Endothelial Growth Factor A
|2 NLM
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| 700 |
1 |
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|a Freund, K Bailey
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ophthalmic surgery, lasers & imaging retina
|d 2013
|g 46(2015), 9 vom: 15. Okt., Seite 907-12
|w (DE-627)NLM224956647
|x 2325-8179
|7 nnns
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| 773 |
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|g volume:46
|g year:2015
|g number:9
|g day:15
|g month:10
|g pages:907-12
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|u http://dx.doi.org/10.3928/23258160-20151008-02
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