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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201503440
|2 doi
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|a eng
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1 |
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|a Hu, Jin
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha
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|c 2015
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|a Text
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|a ƒaComputermedien
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|a Date Completed 13.09.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Genetic fusion of elastin-like polypeptide (ELP) to the C-terminus of interferon alpha (IFN) generates a well-defined IFN-ELP fusion protein with high yield and well-retained bioactivity. The fusion protein significantly enhances pharmacokinetics, tumor accumulation, and antitumor efficacy of interferon alpha in a murine cancer model
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a cancer therapy
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|a elastin-like polypeptides
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|a interferon
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|a pharmacokinetics
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|a protein delivery
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|a Antineoplastic Agents
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|a Interferon-alpha
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| 650 |
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|a Peptides
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| 650 |
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|a Recombinant Fusion Proteins
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|a Elastin
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|a Gao, Weiping
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|g 27(2015), 45 vom: 02. Dez., Seite 7320-4
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