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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b03183
|2 doi
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|a eng
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| 100 |
1 |
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|a Tan, Xinxin
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Single-Molecule Force Spectroscopy of an Artificial DNA Duplex Comprising a Silver(I)-Mediated Base Pair
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|c 2015
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 20.04.2016
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|a Date Revised 20.10.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Single-molecule force spectroscopy measurements of a DNA duplex comprising an artificial metal-mediated base pair are reported. The measurements reveal that DNA duplexes comprising one central imidazole:imidazole mispair rupture at lower forces than a related duplex with canonical base pairs only. In contrast, DNA duplexes with one central imidazole-Ag(+)-imidazole base pair (formed by the addition of Ag(+) to the aforementioned duplex with the mispair) rupture at higher forces. These measurements indicate for the first time that the increase in thermal stability of a nucleic acid duplex that is observed upon the formation of a metal-mediated base pair is accompanied by a concomitant mechanical stabilization. In fact, the mechanical stabilization even exceeds the thermal one. This result indicates that nucleic acids with metal-mediated base pairs should be ideal building blocks for rigid functionalized DNA nano-objects
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Imidazoles
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|a Silver
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|a imidazole
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|a DNA
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1 |
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|a Litau, Stefanie
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1 |
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|a Zhang, Xi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Müller, Jens
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 41 vom: 20. Okt., Seite 11305-10
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|x 1520-5827
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|g volume:31
|g year:2015
|g number:41
|g day:20
|g month:10
|g pages:11305-10
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|u http://dx.doi.org/10.1021/acs.langmuir.5b03183
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