|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM253018269 |
| 003 |
DE-627 |
| 005 |
20250219044403.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2015 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1111/vcp.12292
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0843.xml
|
| 035 |
|
|
|a (DE-627)NLM253018269
|
| 035 |
|
|
|a (NLM)26398102
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Przeździecki, Rafał
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Accuracy of routine cytology and immunocytochemistry in preoperative diagnosis of oral amelanotic melanomas in dogs
|
| 264 |
|
1 |
|c 2015
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 24.10.2016
|
| 500 |
|
|
|a Date Revised 30.12.2016
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2015 American Society for Veterinary Clinical Pathology.
|
| 520 |
|
|
|a BACKGROUND: Amelanotic melanomas are one of the most common oral malignancies. The cytologic and histopathologic differentiation between amelanotic melanoma, sarcoma, and poorly differentiated carcinoma is often difficult or even impossible
|
| 520 |
|
|
|a OBJECTIVES: The aim of this study was to assess the reliability of routine cytology and immunocytochemistry in preoperative diagnosis of canine oral amelanotic melanoma
|
| 520 |
|
|
|a METHODS: Cytologic preparations from undifferentiated canine oral tumors were stained with Giemsa and by immunocytochemistry (ICC) using anti-cytokeratin, anti-vimentin, and anti-Melan A antibodies. The final cytologic diagnosis (including ICC) was compared to the final diagnosis based on histopathology and immunohistochemistry (IHC) results, and sensitivity and specificity of cytologic examination were determined
|
| 520 |
|
|
|a RESULTS: Final cytologic diagnoses of 38 cases agreed well with the histopathologic/immunohistochemical diagnoses, thus both specificity and sensitivity of combined routine cytology and ICC were 100% (95% confidence interval 90.8-100%). Of 32 oral tumors, diagnosis of amelanotic melanoma, sarcoma, and carcinoma was made using routine cytology and ICC. In 4 of 6 aspirates taken from lymph nodes, a preliminary diagnosis of metastatic amelanotic melanoma corresponded with the final diagnosis. Both sensitivity and specificity of routine cytology in diagnosis of amelanotic melanomas were considered moderate (66.7% and 85.7%, respectively)
|
| 520 |
|
|
|a CONCLUSIONS: In conclusion, routine cytology is a reliable diagnostic method for canine oral amelanotic melanoma and metastatic amelanotic melanoma, and ICC, using anti-cytokeratin, anti-vimentin, and anti-Melan A antibodies, is an excellent supporting method for presurgical diagnosis of poorly differentiated oral malignancies in dogs
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Amelanotic melanomas
|
| 650 |
|
4 |
|a Melan A
|
| 650 |
|
4 |
|a cytology
|
| 650 |
|
4 |
|a dog
|
| 650 |
|
4 |
|a immunocytochemistry
|
| 650 |
|
4 |
|a oral cancers
|
| 700 |
1 |
|
|a Czopowicz, Michał
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sapierzyński, Rafał
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 44(2015), 4 vom: 04. Dez., Seite 597-604
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
|
| 773 |
1 |
8 |
|g volume:44
|g year:2015
|g number:4
|g day:04
|g month:12
|g pages:597-604
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/vcp.12292
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 44
|j 2015
|e 4
|b 04
|c 12
|h 597-604
|