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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b01644
|2 doi
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|a pubmed24n0843.xml
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|a (DE-627)NLM252959736
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|a (NLM)26391812
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Nelson, Geoffrey W
|e verfasserin
|4 aut
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| 245 |
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|a Surface Characterization and in situ Protein Adsorption Studies on Carbene-Modified Polymers
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 27.06.2016
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|a Date Revised 13.10.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Polystyrene thin films were functionalized using a facile two-step chemical protocol involving carbene insertion followed by azo-coupling, permitting the introduction of a range of chemical functional groups, including aniline, hexyl, amine, carboxyl, phenyl, phosphonate diester, and ethylene glycol. X-ray photoelectron spectroscopy (XPS) confirmed the success of the two-step chemical modification with a grafting density of at least 1/10th of the typical loading density (10(14)-10(15)) of a self-assembled monolayer (SAM). In situ, real-time quartz crystal microbalance with dissipation (QCM-D) studies show that the dynamics of binding of bovine serum albumin (BSA) are different at each modified surface. Mass, viscoelastic, and kinetic data were analyzed, and compared to cheminformatic descriptors (i.e., c log P, polar surface area) typically used for drug discovery. Results show that functionalities may either resist or adsorb BSA, and uniquely influence its adsorption dynamics. It is concluded that carbene-based surface modification can usefully influence BSA binding dynamics in a manner consistent with, and more robust than, traditional systems based on SAM chemistry
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Polymers
|2 NLM
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|a Proteins
|2 NLM
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|a carbene
|2 NLM
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|a 2465-56-7
|2 NLM
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|a Methane
|2 NLM
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|a OP0UW79H66
|2 NLM
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| 700 |
1 |
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|a Parker, Emily M
|e verfasserin
|4 aut
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1 |
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|a Singh, Kulveer
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Blanford, Christopher F
|e verfasserin
|4 aut
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1 |
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|a Moloney, Mark G
|e verfasserin
|4 aut
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| 700 |
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|a Foord, John S
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 40 vom: 13. Okt., Seite 11086-96
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:31
|g year:2015
|g number:40
|g day:13
|g month:10
|g pages:11086-96
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|u http://dx.doi.org/10.1021/acs.langmuir.5b01644
|3 Volltext
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