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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.08.006
|2 doi
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2 |
|a pubmed24n0843.xml
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|a (DE-627)NLM252922522
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|a (NLM)26387630
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|a (PII)S1521-6616(15)30023-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Roquilly, Antoine
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Role of IL-12 in overcoming the low responsiveness of NK cells to missing self after traumatic brain injury
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|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 29.08.2017
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|a Date Revised 06.02.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Blood samples from 32 patients with severe Traumatic brain injury (TBI) were studied and compared with 11 cardiac surgery patients, and 29 healthy controls. A dramatic decreased expression of HLA class I molecules on monocytes was associated with increased KIR+ NK cell frequency in TBI patients. Overall, the phenotype of TBI NK cells marked by KIR and CD57 expression and lower level of NKp46 and DNAM-1 reflected a differentiated state. The NK-cell response to missing self was marked by lower degranulation and lower IFN-γ production after stimulation with HLA class I deficient cell line. In contrast, the NK-cell ADCC was not altered. IL-12 was able to restore both IFN-γ production and the cytotoxicity capacities of NK cells. This study provides the first extensive description of the phenotype and functions of NK cells in TBI patients. Further evaluation of IL-12 treatment to overcome immunosuppression-induced nosocomial infections is warranted
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|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a HLA class I
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| 650 |
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4 |
|a IL-12
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| 650 |
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|a Immune suppression
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| 650 |
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|a KIR
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| 650 |
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|a Monocytes
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| 650 |
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4 |
|a NK cells
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| 650 |
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|a Traumatic brain injury
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| 650 |
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|a Interleukin-12
|2 NLM
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| 650 |
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|a 187348-17-0
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a David, Gaëlle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cinotti, Raphael
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vourc'h, Mickaël
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morin, Helene
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rozec, Bertrand
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Retière, Christelle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Asehnoune, Karim
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 177(2017) vom: 01. Apr., Seite 87-94
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:177
|g year:2017
|g day:01
|g month:04
|g pages:87-94
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.08.006
|3 Volltext
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