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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1155/2015/846589
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|a eng
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|a Bazovkina, Darya V
|e verfasserin
|4 aut
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|a Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion
|b Comparison with 5-HT2A Receptor Functional Activity
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 19.04.2016
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains. The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice. This effect was receptor-specific because it was inhibited by the 5-HT2C receptor antagonist RS102221. To study the role of genotype in 5-HT2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment. We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice. We also compared the interstrain differences in functional response to 5-HT2C and 5-HT2A receptors activation measured by the quantification of receptor-mediated head-twitches. These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains. Moreover, we found that 5-HT2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice. Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors
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|a Comparative Study
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 5-hydroxytryptamine2C receptor, mouse
|2 NLM
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|a 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione
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|a Amphetamines
|2 NLM
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|a Pyrazines
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|a Receptor, Serotonin, 5-HT2A
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|a Receptor, Serotonin, 5-HT2C
|2 NLM
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|a Serotonin 5-HT2 Receptor Agonists
|2 NLM
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|a Spiro Compounds
|2 NLM
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|a Sulfonamides
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| 700 |
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|a Kondaurova, Elena M
|e verfasserin
|4 aut
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| 700 |
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|a Naumenko, Vladimir S
|e verfasserin
|4 aut
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| 700 |
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|a Ponimaskin, Evgeni
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2015(2015) vom: 10., Seite 846589
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnns
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| 773 |
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|g volume:2015
|g year:2015
|g day:10
|g pages:846589
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|u http://dx.doi.org/10.1155/2015/846589
|3 Volltext
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