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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erv418
|2 doi
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|a pubmed24n0842.xml
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|a (DE-627)NLM252609875
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|a (NLM)26355149
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhao, Shujuan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Enhancing diterpenoid concentration in Salvia miltiorrhiza hairy roots through pathway engineering with maize C1 transcription factor
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.10.2016
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Tanshinones are valuable natural diterpenoids from danshen (Salvia miltiorrhiza Bunge). Here, it was demonstrated that maize transcription factor C1 improved the accumulation of tanshinones by comprehensively upregulating the pathway genes, especially SmMDC and SmPMK in danshen hairy roots, yielding total tanshinones up to 3.59mg g(-1) of dry weight in line C1-6, a 3.4-fold increase compared with the control. Investigation of 2024bp of the SmMDC promoter fragment revealed that C1-mediated upregulation of terpenoid genes was possibly due to the direct interaction of C1 with its recognition sequences. The increase of tanshinones was accompanied by a decrease of salvianolic acid production, the other bioactive ingredient in danshen, by up to 37% compared with the control. This was the result of the downregulation of SmTAT, the entry-point gene of the tyrosine pathway, which promoted metabolic flow to anthocyanins rather than to salvianolic acids. Based on the findings of the present study, it was concluded that cis-acting elements shared by terpenoid and phenylpropanoid biosynthetic genes are partially responsible for the C1-stimulated variation of tanshinone and salvianolic acid concentrations
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Hairy roots
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|a Salvia miltiorrhiza Bunge
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|a ZmC1.
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|a regulation
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|a salvianolic acids
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| 650 |
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|a tanshinones
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|a C1 protein, Zea mays
|2 NLM
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| 650 |
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|a DNA-Binding Proteins
|2 NLM
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| 650 |
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|a Diterpenes
|2 NLM
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| 650 |
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|a Plant Proteins
|2 NLM
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| 650 |
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|a Transcription Factors
|2 NLM
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| 700 |
1 |
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|a Zhang, Jinjia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Ronghui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Xiaoyu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 66(2015), 22 vom: 10. Dez., Seite 7211-26
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:66
|g year:2015
|g number:22
|g day:10
|g month:12
|g pages:7211-26
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|u http://dx.doi.org/10.1093/jxb/erv418
|3 Volltext
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