Ubiquitin-conjugated degradation of golden 2-like transcription factor is mediated by CUL4-DDB1-based E3 ligase complex in tomato

Ubiquitin-conjugated degradation of golden 2-like transcription factor is mediated by CUL4-DDB1-based E3 ligase complex in tomato

© 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 209(2016), 3 vom: 14. Feb., Seite 1028-39
1. Verfasser: Tang, Xiaofeng (VerfasserIn)
Weitere Verfasser: Miao, Min, Niu, Xiangli, Zhang, Danfeng, Cao, Xulv, Jin, Xichen, Zhu, Yunye, Fan, Youhong, Wang, Hongtao, Liu, Ying, Sui, Yuan, Wang, Wenjie, Wang, Anquan, Xiao, Fangming, Giovannoni, Jim, Liu, Yongsheng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't 26S proteasome cullin4-DDB1-DET1 complex golden 2-like transcription factor tomato (Solanum lycopersicum) ubiquitin-conjugated degradation Plant Proteins Transcription Factors Ubiquitin mehr... Ubiquitin-Protein Ligases EC 2.3.2.27 Proteasome Endopeptidase Complex EC 3.4.25.1
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520 |a CULLIN4-RING ubiquitin ligases (CRL4s) as well as their targets are fundamental regulators functioning in many key developmental and stress responses in eukaryotes. In tomato (Solanum lycopersicum), molecular cloning has revealed that the underlying genes of natural spontaneous mutations high pigment 1 (hp1), high pigment 2 (hp2) and uniform ripening (u) encode UV-DAMAGED DNA BINDING PROTEIN 1 (DDB1), DE-ETIOLATED 1 (DET1) and GOLDEN 2-LIKE (GLK2), respectively. However, the molecular basis of the opposite actions of tomato GLK2 vs CUL4-DDB1-DET1 complex on regulating plastid level and fruit quality remains unknown. Here, we provide molecular evidence showing that the tomato GLK2 protein is a substrate of the CUL4-DDB1-DET1 ubiquitin ligase complex for the proteasome degradation. SlGLK2 is degraded by the ubiquitin-proteasome system, which is mainly determined by two lysine residues (K11 and K253). SlGLK2 associates with the CUL4-DDB1-DET1 E3 complex in plant cells. Genetically impairing CUL4, DDB1 or DET1 results in a retardation of SlGLK2 degradation by the 26S proteasome. These findings are relevant to the potential of nutrient accumulation in tomato fruit by mediating the plastid level and contribute to a deeper understanding of an important regulatory loop, linking protein turnover to gene regulation 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a 26S proteasome 
650 4 |a cullin4-DDB1-DET1 complex 
650 4 |a golden 2-like transcription factor 
650 4 |a tomato (Solanum lycopersicum) 
650 4 |a ubiquitin-conjugated degradation 
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650 7 |a Transcription Factors  |2 NLM 
650 7 |a Ubiquitin  |2 NLM 
650 7 |a Ubiquitin-Protein Ligases  |2 NLM 
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650 7 |a Proteasome Endopeptidase Complex  |2 NLM 
650 7 |a EC 3.4.25.1  |2 NLM 
700 1 |a Miao, Min  |e verfasserin  |4 aut 
700 1 |a Niu, Xiangli  |e verfasserin  |4 aut 
700 1 |a Zhang, Danfeng  |e verfasserin  |4 aut 
700 1 |a Cao, Xulv  |e verfasserin  |4 aut 
700 1 |a Jin, Xichen  |e verfasserin  |4 aut 
700 1 |a Zhu, Yunye  |e verfasserin  |4 aut 
700 1 |a Fan, Youhong  |e verfasserin  |4 aut 
700 1 |a Wang, Hongtao  |e verfasserin  |4 aut 
700 1 |a Liu, Ying  |e verfasserin  |4 aut 
700 1 |a Sui, Yuan  |e verfasserin  |4 aut 
700 1 |a Wang, Wenjie  |e verfasserin  |4 aut 
700 1 |a Wang, Anquan  |e verfasserin  |4 aut 
700 1 |a Xiao, Fangming  |e verfasserin  |4 aut 
700 1 |a Giovannoni, Jim  |e verfasserin  |4 aut 
700 1 |a Liu, Yongsheng  |e verfasserin  |4 aut 
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