Altered B-cell subsets and functional B-cell defects in selective IgM deficiency

Primary selective IgM deficiency (sIgM) is characterized by diminished serum IgM, infections and autoimmunity. Although there is some evidence of B-cell defects the pathogenesis of sIgM is poorly understood. We determined peripheral B-cell subsets and IgM-expression levels in 31 adult sIgM patients...

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Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 161(2015), 2 vom: 08. Dez., Seite 96-102
Auteur principal:	Mensen, Angela (Auteur)
Autres auteurs:	Krause, Torben, Hanitsch, Leif Gunnar, Meisel, Christian, Kleint, Maximilian E, Volk, Hans-Dieter, Na, Il-Kang, Scheibenbogen, Carmen
Format:	Article en ligne
Langue:	English
Publié:	2015
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Antibody-secreting cells ELISpot assay Memory B cells Primary immunodeficiency Selective IgM deficiency Transitional B cells Antibodies Immunoglobulin M