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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.08.014
|2 doi
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|a pubmed25n0841.xml
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|a (DE-627)NLM252474597
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|a (NLM)26341315
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|a (PII)S1521-6616(15)30030-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chujo, Daisuke
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood
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| 264 |
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|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.03.2016
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|a Date Revised 23.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a The breakdown of immune tolerance against islet antigens causes type 1 diabetes (T1D). The antigens associated with adult-onset T1D (AT1D) remain largely undefined. It is possible that AT1D patients display a unique type of CD4(+) T cells specific for a certain islet antigen. Here we analyzed the cytokine production profiles of CD4(+) helper T (Th) cells that are specific for three islet antigens; GAD65, preproinsulin, and IGRP in patients with AT1D, juvenile-onset T1D (JT1D), and age-, gender- and human leukocyte antigen (HLA)-matched control adults. While IGRP-specific Th cells in AT1D patients were dominantly Th1 cells, IGRP-specific Th cells in control adults and JT1D patients were dominantly Th2 and T regulatory type 1 (Tr1) cells. Notably, the frequency of IGRP-specific Tr1 cells was significantly lower in AT1D patients than in control adults and JT1D patients. In conclusion, our study suggests that IGRP-specific Th cells play a unique pathogenic role in AT1D
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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4 |
|a CD4 T cells
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|a Islet antigens
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|a Islet-specific glucose 6 phosphatase catalytic subunit-related protein
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| 650 |
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|a T regulatory type 1 (Tr1) cells
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| 650 |
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|a Type 1 diabetes
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|a Cytokines
|2 NLM
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|a Insulin
|2 NLM
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| 650 |
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|a Protein Precursors
|2 NLM
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| 650 |
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|a preproinsulin
|2 NLM
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| 650 |
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|a 61116-24-3
|2 NLM
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| 650 |
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|a Glucose-6-Phosphatase
|2 NLM
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| 650 |
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7 |
|a EC 3.1.3.9
|2 NLM
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| 650 |
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|a G6PC2 protein, human
|2 NLM
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| 650 |
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7 |
|a EC 3.1.3.9.
|2 NLM
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| 650 |
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|a GAD55, human
|2 NLM
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| 650 |
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|a EC 4.1.1.15
|2 NLM
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| 650 |
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|a Glutamate Decarboxylase
|2 NLM
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| 650 |
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7 |
|a EC 4.1.1.15
|2 NLM
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| 700 |
1 |
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|a Nguyen, Thien-Son
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Foucat, Emile
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Blankenship, Derek
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Banchereau, Jacques
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nepom, Gerald T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chaussabel, Damien
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ueno, Hideki
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 161(2015), 2 vom: 14. Dez., Seite 270-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:161
|g year:2015
|g number:2
|g day:14
|g month:12
|g pages:270-7
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2015.08.014
|3 Volltext
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|a GBV_ILN_11
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 161
|j 2015
|e 2
|b 14
|c 12
|h 270-7
|