Nanotheranostics Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

Nanotheranostics : Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 27(2015), 37 vom: 07. Okt., Seite 5499-505
1. Verfasser: Hu, Bingbing (VerfasserIn)
Weitere Verfasser: Dai, Fengying, Fan, Zhanming, Ma, Guanghui, Tang, Qunwei, Zhang, Xin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Alzheimer's disease H2O2-responsive magnetic resonance imaging nanotheranostics therapy APP protein, human Amyloid beta-Protein Precursor Contrast Media mehr... Drug Carriers Ferric Compounds Magnetite Nanoparticles Neuroprotective Agents PSEN1 protein, human Presenilin-1 ferric oxide 1K09F3G675 Congo Red 3U05FHG59S Rutin 5G06TVY3R7 Hydrogen Peroxide BBX060AN9V
Beschreibung
Zusammenfassung:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress
Beschreibung:Date Completed 06.07.2016
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201502227